Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-120-4
CAS number: 12070-08-5
An OECD 420 study is available on TiO2. LD0 = 5000 mg/kg bw.
In an acute oral
toxicity study according to OECD guideline 420 (fixed dose procedure),
groups of fasted,
CD-1 mice (10 males and 10 females) were given a single oral dose of Titanium
dioxide (>99%) in
0.5 % hydroxypropylmethylcellulose K4M (HPMC, K4M) at a dose of 5 g/kg
body weight and were observed for 14 days. An oral LD50 (males/females)
of more than
5 g/kg body weight could be established. As none of the animals died the
LD0 is 5 g/kg body weight.
In an acute oral
toxicity study according to OECD 420, groups off
10 mice/sex/dose were given a single oral dose of Titanium
mg/kg bw) and were observed for 14 days. No mortality occurred. The
bioaccessibility of TiC in artificial interstitial fluid is below the
limit of detection (< 50µg/g sample). Thus, systemic exposure via
inhalation is expected to be even lower than via the gastro-intestinal
Titanium carbide is considered to have a very low potential for acute
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again