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EC number: 235-120-4
CAS number: 12070-08-5
No effects were observed on the body weights
and the lymph node weights of the animals tested with titanium carbide.
No other signs of toxicity were seen in any of the animals.
Table 1: Mean weight of lymph nodes.
Mean of test group
12.5% TiC in vehicle
25% TiC in vehicle
50% TiC in vehicle
In this dermal sensitization study with
titanium carbide in acetone/olive oil 4:1 (v/v), young adult female
CBA/CaOlaHsD mice were tested using the Local Lymph Node Assay (LLNA).
25 µl of the test substance in solvent were applied on the entire
dorsal ear surface of each animal. The following concentrations were
used: 12.5, 25 and 50%. Acetone/olive oil 4:1 was used as negative
control. Phenylenediamine was tested as a positive control in a prior
assay. The application was repeated daily for three consecutive days.
The doses applied were selected based on a pre-screening assay.
Five days after the 1st application 250 µL 20 µCi 3H-methyl
thymidine was injected intravenously to all mice (diluted
concentration: 80 µCi/mL). All animals were sacrificed five hours
after the aforementioned injection. The draining ear lymph nodes were
excised into PBS and single cell suspension of lymphocyte was
isolated. Cells were precipitated with 5% trichloroacetic acid at 4 °C
for 18 hours.The radioactivity was measured in a ß-counter.
Stimulation indices (ratio of 3H-methyl
thymidine incorporation into lymph node of test animals relative to
that for control animals)≥ 3 were considered a positive response. The
results revealed the following SI: 1.8, 1.7 and 1.9 for the
concentrations of 12.5, 25 and 50%, respectively. No signs of toxicity
were detected in any of the treated animals. In this study,
Titanimum carbide is not a dermal sensitizer.
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