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EC number: 235-120-4
CAS number: 12070-08-5
The 48 hr toxicity of TiO2 nanoparticles to juveniles (sac fry stage < 24 h) of Danio rerio (zebrafish) was studied under static conditions. Embryos were exposed to TiO2 at concentrations ranging between 0 (control) and 10 mg/L nominal concentration. Mortality was observed every 12h.
The 48 hour LC50 was > 10 mg/L (nominal concentration).
This information is used in a read-across approach in the assessment of the target substance.
For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
The 48 hr toxicity of TiO2 nanoparticles to
juveniles (sac fry stage < 24 h) of Danio rerio (zebrafish) was
studied under static conditions. Embryos were exposed to TiO2 at
concentrations ranging between 0 (control) and 10 mg/L nominal
concentration. Mortality was observed every 12h.
The 48 hour LC50was > 10 mg/L
Titanium carbide was not tested for long-term toxicity to fish, and read-across to titanium dioxide was used for this endpoint. No deaths were observed at saturation concentration under exposure conditions in a toxicity test on embryo and sac-fry stages of Danio rerio with titanium dioxide. The NOEC is 10 mg TiO2/L.
Griffitt et al. (2008)
conducted a test with Danio rerio (zebrafish) similar to OECD Guideline
212 (Fish, Short-term Toxicity Test on Embryo and Sac-Fry Stages). This
test is considered relevant in the evaluation of chronic toxicity to
fish (see ECHA Guidance R.7b).
Sac fry stages of
zebrafish were exposed to TiO2 nanoparticles for 48 h at concentrations
up to 10 mg/L (nominal). Mortality, evaluated by direct observation
under light microscopy (death = lack of a visible heartbeat for 30 s and
lack of response to physical prodding), was assessed every 12h. No
mortality was observed at all concentrations tested.
Due to lower
transformation/dissolution results for titanium carbide (the target
substance) than titanium dioxide (the source substance), the resulting
toxicity potential would also be expected to be lower. Therefore, the
dose descriptors are expected to be sufficiently higher for the target
substance, and read-across to the source chemical is adequately
protective (for more details refer to the attached description of the
read-across approach). In
fact, (eco-) toxicologically relevant release of Ti ions from titanium
carbide is not expected as the concentration of soluble Ti ions was
below the method detection limit (< 0.4 µg/L) in the T/D test. Thus, TiC
in considered to be practically insoluble, hence release of Ti ions to
any ecotoxicologically relevant extent (and potential subsequent
formation of soluble and/or insoluble Ti compounds) is not expected.
Therefore, any long-term toxic effects for fish are not expected to
arise from TiC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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