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EC number: 235-120-4
CAS number: 12070-08-5
Table 1: Experimental results of the
EPISKIN-SM test after application of Titanium carbide powder.
Mean OD550of 3 replicate tissues (blank-corrected
Relative tissue viabilities (%)
Mean relative tissue viability (%)
SD tissue viability (%)
CV (% viability)
In this in vitro dermal irritation
study with the three-dimensional human skin model EPISKIN-SM conducted
according to OECD TG 439, the irritation potential of Titanium carbide
was examined. The test substance (10 mg) was applied topically on the
tissue for 15 min, and thereafter the exposed tissue culture was
incubated for 42 h. A positive and a negative control were used. The
determination of cytotoxic effects was performed with the MTT assay.
Irritation potential of the test susbstance was determined based on the
cytotoxicity observed (mean tissue viability). All acceptability
criteria were fulfilled. The results revealed a mean relative tissue
viability higher than 50%, and hence, the test substance is not a skin
irritant under the conditions of this test.
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