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EC number: 235-120-4
CAS number: 12070-08-5
Table 1: Experimental results of the EPISKIN-SM test after
application of Titanium carbide powder.
Mean OD550of 3 replicate tissues (blank-corrected
Relative tissue viabilities (%)
Mean relative tissue viability (%)
SD tissue viability (%)
CV (% viability)
In this in vitro dermal irritation study with the
three-dimensional human skin model EPISKIN-SM, the irritation potential
of Titanium carbide was examined. The test substance was applied
topically on the tissue for 15 min, and thereafter the exposed tissue
culture was incubated for 42 h. A positive and a negative control were
used. The determination of cytotoxic effects was performed with the MTT
assay. Irritation potential of the test susbstance was determined based
on the cytotoxicity observed (mean tissue viability). The results
revealed a mean relative tissue viability higher than 50%, and hence,
the test substance is not a skin irritant under the conditions of this
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