Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Toxicity Evaluation of Trisodium Nitrilotriacetate
Author:
Nixon, G.A.
Year:
1971
Bibliographic source:
Toxicol. Appl. Pharmacol. 22, p. 297

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trisodium nitrilotriacetate
EC Number:
225-768-6
EC Name:
Trisodium nitrilotriacetate
Cas Number:
5064-31-3
Molecular formula:
C6H9NO6.3Na
IUPAC Name:
trisodium 2-[bis(carboxylatomethyl)amino]acetate
Details on test material:
- Name of test material (as cited in study report): Trisodium Nitrilotriacetate
- Physical state: liquid, aqueuous solution of 20% (w/v) and 50% (w/w)
- no further details

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
20% & 50% no data on volume
No. of animals per sex per dose:
no data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
254 mg/kg bw
Remarks on result:
other: 50% NA3NTA
Sex:
not specified
Dose descriptor:
LD50
Effect level:
446 mg/kg bw
Remarks on result:
other: 20% Na3NTA

Applicant's summary and conclusion

Conclusions:
The i.p. LD 50 values in rats were found to be 254 mg/kg (50% Na3NTA) and 446 mg/kg (20% Na3NTA). No unusual symptoms were observed in any ot the animals following injection. All surviving animals appeared normal 24 h after dosing. I.p. injection is not considered relevant for human hazard assessment.