Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-768-6 | CAS number: 5064-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- Cited as Directive 84/449/EEC, B.1
- GLP compliance:
- no
Test material
- Reference substance name:
- trisodium 2-[bis(carboxylatomethyl)amino]acetate hydrate
- EC Number:
- 606-091-9
- Cas Number:
- 18662-53-8
- Molecular formula:
- C6H8NNa3O7
- IUPAC Name:
- trisodium 2-[bis(carboxylatomethyl)amino]acetate hydrate
- Details on test material:
Na3.NTA.H2O ("TRILON A92"), solid, not further
specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Acclimatization period: at least 1 week. Type of cage: stainless steel wire mesh cages. No. of animals per cage: 5. Animal identification using cage cards. Room temperature/rel. humidity: fully air-conditioned rooms, 20-24°C, 30-70% relative humidity. Day/night rhythm: 12 h. Drinking water: ad libitum. Diet: Kliba-Labordiaet. Animal weights: males 176 - 188 g, females 176 - 182 g. Fasting period: 16 h before administration.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 1000, 1470, 2150, 2610 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Recording of signs and symptoms several times on the day of administration, at least once each workday. Check for moribund and dead animals twice each workday and once on holidays.
Withdrawal of food 16 hours before sacrifice with CO2; then necropsy with gross-pathological examination. Necropsy of all animals that die as early as possible.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 740 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 470 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 220 mg/kg bw
- Mortality:
- Males: After 14 d: 2610 mg/kg 3/5, 2150 mg/kg 2/5, 1470 mg/kg 2/5, 1000 mg/kg 0/5
Females: After 14 d: 2610 mg/kg 5/5, 2150 mg/kg 5/5, 1470 mg/kg 3/5, 1000 mg/kg 0/5 - Clinical signs:
- other: Dyspnea, apathy, abnormal position, staggering, twitching, opisthotonus, tonic convulsions, piloerection, salivation, poor general state
- Gross pathology:
- Animals that died: hyperemic glandular-stomach; mucosa with multiple hemorrhagic erosions.
Sacrificed animals: nothing abnormal detected.
Any other information on results incl. tables
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
