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EC number: 225-768-6 | CAS number: 5064-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Ten milligrams [14C]NTA in gelatin capsules was given (p.o.) to 8 male subjects. Blood samples were taken, and samples of urine and feces were collected. In addition, expired CO2 was collected in 4 of the subjects. NTA is poorly absorbed since approximately 12% of the dose appeared in the urine. The compound is rapidly excreted in the urine since 87 % of the absorbed dose was excreted within the first 24 hr post dosing. The blood concentration peak occurred 1-2 hr after dosing. Reverse isotope dilution and thin-layer chromatography showed the urinary radioactivity to be unchanged NTA, and therefore no biotransformation had occurred. These results closely resemble the rat and dog metabolic data except that rats and dogs absorb 4 times more NTA than humans. The metabolic similarities among rats, dogs and humans lends some confidence to the extrapolation of the results derived from rat and dog toxicity tests for the purpose of estimating human safety.
Literature: Budny, J.A. and Arnold, J.D. (1973). Human Metabolism and its Importance in the Total Safety Evaluation Program. Tox. Appl. Pharmacol. 25, 48 - 53 (cited in MAK documentation 2008).
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