Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-768-6 | CAS number: 5064-31-3
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Arthur et al (1974) presents 21 week NOEC results of 9.3 mg/L Na3NTA for survival for the amphipod, Gammarus pseudolimnaeus.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 9.3 mg/L
Additional information
Arthur et al (1974) presents 21 week NOEC results of 9.3 mg/L Na3NTA for survival and 19 mg/L Na3NTA for reproduction for the amphipod, Gammarus pseudolimnaeus. Study was performed by exposing 18 day old amphipods to measured concentrations of NA3NTA for 21 weeks. Mortality and reproduction were assessed. However, control survival was only 56% which does not meet validity requirements. In addition, Flannagan (1974) exposed snails (Helisoma trivolvis) to Na3NTA concentrations for 120 days resulting in a NOEC of 12.5 mg/L Na3NTA. Due to the age of this study, some testing information is missing and it was not possible to fulfill a robust study summary. Results of both Arthur et al. (1974) and Flannagan (1974) studies are within the same range and can be used as weight of evidence in predicting the toxicity of Na3NTA to aquatic invertebrates. Canton and Slooff (1982) provided 21 -day NOEC of 100 mg/L, based on mortality and reproduction, for Daphnia magna. However, this study is considered unreliable due to lack of testing information.
Table 1. Summary of Long-term Toxicity to Freshwater Invertebrates
| Guideline | Species | Effect Concentration | Reference | Reliability |
| no guideline available | Gammarus psuedolimnaeus | 21 week NOEC = 9.3 mg/L NTA for survival and 18.7 mg/L for reproduction | Arthur et al. (1974) | 2- reliable with restrictions |
| OECD 211 | Daphnia magna | 21 -d NOEC = 100 mg/L for survival and reproduction | Canton and Slooff (1982) | 3 - not reliable |
| Helisoma trivolvis | 120 -d NOEC = 12.5 mg/L for growth | Flannagan (1974) | 2- reliable with restrictions |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
