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Long-term toxicity to aquatic invertebrates

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Description of key information

Arthur et al (1974) presents 21 week NOEC results of 9.3 mg/L Na3NTA for survival for the amphipod, Gammarus pseudolimnaeus.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
9.3 mg/L

Additional information

Arthur et al (1974) presents 21 week NOEC results of 9.3 mg/L Na3NTA for survival and 19 mg/L Na3NTA for reproduction for the amphipod, Gammarus pseudolimnaeus. Study was performed by exposing 18 day old amphipods to measured concentrations of NA3NTA for 21 weeks. Mortality and reproduction were assessed. However, control survival was only 56% which does not meet validity requirements. In addition, Flannagan (1974) exposed snails (Helisoma trivolvis) to Na3NTA concentrations for 120 days resulting in a NOEC of 12.5 mg/L Na3NTA. Due to the age of this study, some testing information is missing and it was not possible to fulfill a robust study summary. Results of both Arthur et al. (1974) and Flannagan (1974) studies are within the same range and can be used as weight of evidence in predicting the toxicity of Na3NTA to aquatic invertebrates. Canton and Slooff (1982) provided 21 -day NOEC of 100 mg/L, based on mortality and reproduction, for Daphnia magna. However, this study is considered unreliable due to lack of testing information.

Table 1. Summary of Long-term Toxicity to Freshwater Invertebrates

 Guideline  Species  Effect Concentration  Reference  Reliability
no guideline available Gammarus psuedolimnaeus 21 week NOEC = 9.3 mg/L NTA for survival and 18.7 mg/L for reproduction  Arthur et al. (1974)  2- reliable with restrictions 
 OECD 211  Daphnia magna  21 -d NOEC = 100 mg/L for survival and reproduction  Canton and Slooff (1982) 3 - not reliable 
   Helisoma trivolvis  120 -d NOEC = 12.5 mg/L for growth  Flannagan (1974)  2- reliable with restrictions

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