Trisodium nitrilotriacetate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and accptable for assessment

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Trisodium nitrilotriacetate

EC Number:

225-768-6

EC Name:

Trisodium nitrilotriacetate

Cas Number:

5064-31-3

Molecular formula:

C6H9NO6.3Na

IUPAC Name:

trisodium 2-[bis(carboxylatomethyl)amino]acetate

Details on test material:

- Name of test material (as cited in study report):CP56453, Monsanto Sample no. 173
- Physical state: solid
- Other: no detailed data provided

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

water

Duration of exposure:

24 h

Doses:

500, 1000, 2000 mg/kg bw. as a 10% aqueous solution

No. of animals per sex per dose:

1/1

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD0

Effect level:

2 000 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

The highest application of 2000 mg/kg bw was found to be non-lethal by skin absorption in male and female rabbits.

Executive summary:

In an acute dermal toxicity study three male and female rabbits were dermally exposed to Na3NTA in water (10 % aqueous solution) for 24 hours at doses of 500, 1000, and 2000 mg/kg bw.

No mortality occurred – not even at highest concentration of 2000 mg/kg bw.

According to expert judgment trisodium nitrilotriacetate practically non-toxic by skin absorption. There were no symptoms of systemic toxicity observed. No weekness or loss of appetite. Since there was no death, no autopsies were performed.