Registration Dossier
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EC number: 225-768-6 | CAS number: 5064-31-3
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Arthur et al (1974) presents 32 week NOEC results of >54 mg/L NTA for survival and reproduction for the fathead minnow, Pimephales promelas.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 54 mg/L
Additional information
Arthur et al (1974) presents 32 week NOEC results of >54 mg/L NTA for survival and reproduction for the fathead minnow, Pimephales promelas. Study was performed by exposing 3 -15 day old fry to measured concentrations of NTA for 32 weeks. Mortality, spawing activity and hatchability were assessed. The F1 generation was exposed for 30 days to NTA and growth assessed. A 30 day NOEC of > 60.2 mg/L was presented for the growth rate of the F1 generation. Birge et al. (1979) exposed rainbow trout embryos for 27 days (4 days post-hatch) to measured concentrations of NTA at two different hardnesses. Mortality was assessed at hatch and 4 days post-hatch. The27 day LC50 for 50 mg/L hardness test = 90.5 mg/L and, for 200 mg/L hardness test the LC50 = 114 mg/L. This study is considered supporting.
This study was chosen as key study as it was the most sensitive reliable data for long-term toxicity of NTA to freshwater fish.
Table 1. Summary of Long-term Toxicity to Freshwater Fish
| Guideline | Species | Effect Concentration | Reference | Reliability |
| similar to fish life-cycle test | Pimephales promelas | 32 week NOEC = >54 mg/L NTA for survival and reproduction | Arthur et al. (1974) | 2- reliable with restrictions |
| embryo-larval test | Oncorhyncus mykiss | 27 day LC50 for 50 mg/L hardness test = 90.5 mg/L 27 day LC50 for 200 mg/L hardness test = 114 mg/L |
Birge et al. (1979) | 2- reliable with restrictions |
| / | not reported | NOEC = 10 mg/L | Brouwer & Terpstra (1994) | 4 - not assignable (secondary reference) |
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