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EC number: 466-470-8
CAS number: -
The primary eye irritation potential of the test item was investigated according to OECD test guideline no. 405 in a GLP certified laboratory. The test item was applied by instillation of 0.1 g into the left eye of each of three young adult New Zealand White rabbits. Scoring of irritation effects was performed approximately 1, 24, 48 and 72 hours, as well as 7, 10, 14, 17 and 21 days after test item instillation. The mean score was calculated across 3 scoring times (24, 48 and 72 hours after instillation) for each animal for corneal opacity, iris, redness and chemosis of the conjunctivae, separately. The individual mean scores for corneal opacity and iris were 0.00 for all three animals. The individual mean scores for the conjunctivae were 1.00, 0.67 and 0.67 for reddening and 0.00 for chemosis for all three animals, respectively. The instillation of test item into the eye resulted in mild and early-onset ocular changes, such as corneal opacity, reddening of the conjunctivae and sclerae and discharge. Slight to marked black staining of the treated eyes was noted in all animals at the 1-hour reading and persisted as slight staining in all animals until the 21-day reading, the end of the observation period for all animals. Black remnants were observed in the eye or conjunctival sac of all the rabbits from 1 hour to 72 hours after application. No abnormal findings were observed in the iris of any animal at any of the examinations. No corrosion was observed at any of the measuring intervals. No clinical signs were observed. Based on the results of the study, the test article is irritant to the eye of rabbits (Stains the eyes).
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