Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study (GLP)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 402, EC B.3, OPPTS 870.1200
Deviations:
yes
Remarks:
24 hours exposure
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea
EC Number:
500-057-6
EC Name:
Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea
Cas Number:
27104-30-9
IUPAC Name:
500-057-6
Details on test material:
AFLAMMIT SAP, batch no 175594 806, expiration date 30 June 2008, manufacturer is Thor GmbH_ Speyer_ Germany.

Test animals

Species:
rat
Strain:
Wistar

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
no
Amount / concentration applied:
2000 mg/kg bw
Duration of treatment / exposure:
24 hours
Observation period:
14 days
Number of animals:
5m, 5fm

Results and discussion

In vivo

Results
Irritation parameter:
other: scar formation
Basis:
animal #3
Time point:
other: day 9 post exposure
Score:
1
Max. score:
1
Reversibility:
not reversible
Remarks on result:
other: female rats

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
2000 mg/kg bw of Aflammit SAP is corrosive to skin after 24 hours exposure. Scar formation becomes visible at day 9 post application.