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EC number: 204-707-7 | CAS number: 124-64-1
Endpoint summary
Administrative data
Description of key information
rat oral LD50 = 161 mg/kg (NTP 1987)
rat dermal LD50 > 1500 mg/kg bw (Ulsamer 1980)
rabbit dermal LD50 = 281 mg/kg (Am.Cyanamid 1975/CPSC 2001)
inhalation LC50 (test waived: corrosive + limited exposure)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Published test report from National Toxicology Program (US). Evaluated data from a reliable secondary source (US-CPSC).
- Principles of method if other than guideline:
- see attached tables (results)
- GLP compliance:
- not specified
- Remarks:
- NTP study
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were housed five per cage. Feed and water were avaliable ad libitum.
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 75, 150, 300, 600, 1200 (mg/kg bw)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Statistics:
- Spearman-Karber
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 185 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- 141 - 242
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 161 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- 115 - 224
- Mortality:
- All male and female rats that received 600 or 1200 mg/kg THPC and all males that received 300 mg/kg THPC were dead by day 2.
- Clinical signs:
- Surviving rats of each sex that received 150 mg/kg had reddish fluid around the nostrils by day 3 and labored breathing.
- Body weight:
- final weights were not recorded.
- Gross pathology:
- Necropsies were not performed.
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Migrated information: rat oral LD50 = 161 mg/kg
- Conclusions:
- rat oral LD50 = 161 mg/kg
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 161 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published data from peer reviewed journal. Evaluated data from a reliable secondary source (US-CPSC).
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- dermal LD50 study, 24 h exposure
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- albino rabbits
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- 4,084 mg/kg (body weight)
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- not applicable: no deaths occourred.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 4 084 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no deaths (at limit dose)
- Clinical signs:
- varying degrees of erythema and edema of the (integumentary system) treated skin.
- Body weight:
- no data
- Gross pathology:
- no data
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 (rabbit) is greater then 4084 mg/kg bw.
- Executive summary:
acute dermal LD50 (rabbit) > 4084 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 281 mg/kg bw
Additional information
Justification for classification or non-classification
Acute Tox 3, H301 Toxic if swallowed
Acute Tox 3, H311 Toxic in contact with skin
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