Registration Dossier
Registration Dossier
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EC number: 204-707-7 | CAS number: 124-64-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Published test report from National Toxicology Program (US). Evaluated data from a reliable secondary source (US-CPSC).
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
- Principles of method if other than guideline:
- see attached tables (results)
- GLP compliance:
- not specified
- Remarks:
- NTP study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrakis(hydroxymethyl)phosphonium chloride
- EC Number:
- 204-707-7
- EC Name:
- Tetrakis(hydroxymethyl)phosphonium chloride
- Cas Number:
- 124-64-1
- Molecular formula:
- C4H12O4P.Cl
- IUPAC Name:
- tetrakis(hydroxymethyl)phosphonium chloride
- Details on test material:
- 80% (nominal) aqueous solution of THPC.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were housed five per cage. Feed and water were avaliable ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 75, 150, 300, 600, 1200 (mg/kg bw)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Statistics:
- Spearman-Karber
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 185 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- 141 - 242
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 161 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- 115 - 224
- Mortality:
- All male and female rats that received 600 or 1200 mg/kg THPC and all males that received 300 mg/kg THPC were dead by day 2.
- Clinical signs:
- Surviving rats of each sex that received 150 mg/kg had reddish fluid around the nostrils by day 3 and labored breathing.
- Body weight:
- final weights were not recorded.
- Gross pathology:
- Necropsies were not performed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Migrated information: rat oral LD50 = 161 mg/kg
- Conclusions:
- rat oral LD50 = 161 mg/kg
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