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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Published test report from National Toxicology Program (US). Evaluated data from a reliable secondary source (US-CPSC).

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1987
Report date:
1987
Reference Type:
secondary source
Title:
Unnamed
Year:
1999
Report date:
1999

Materials and methods

Principles of method if other than guideline:
see attached tables (results)
GLP compliance:
not specified
Remarks:
NTP study
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrakis(hydroxymethyl)phosphonium chloride
EC Number:
204-707-7
EC Name:
Tetrakis(hydroxymethyl)phosphonium chloride
Cas Number:
124-64-1
Molecular formula:
C4H12O4P.Cl
IUPAC Name:
tetrakis(hydroxymethyl)phosphonium chloride
Details on test material:
80% (nominal) aqueous solution of THPC.

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female
Details on test animals or test system and environmental conditions:
Animals were housed five per cage. Feed and water were avaliable ad libitum.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
75, 150, 300, 600, 1200 (mg/kg bw)
No. of animals per sex per dose:
5
Control animals:
no
Statistics:
Spearman-Karber

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
185 mg/kg bw
Based on:
act. ingr.
95% CL:
141 - 242
Sex:
female
Dose descriptor:
LD50
Effect level:
161 mg/kg bw
Based on:
act. ingr.
95% CL:
115 - 224
Mortality:
All male and female rats that received 600 or 1200 mg/kg THPC and all males that received 300 mg/kg THPC were dead by day 2.
Clinical signs:
Surviving rats of each sex that received 150 mg/kg had reddish fluid around the nostrils by day 3 and labored breathing.
Body weight:
final weights were not recorded.
Gross pathology:
Necropsies were not performed.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Remarks:
Migrated information: rat oral LD50 = 161 mg/kg
Conclusions:
rat oral LD50 = 161 mg/kg