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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics, other
Remarks:
read-across from a variety of sources
Type of information:
other: review
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
read-across from a variety of sources

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2005

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Other: members of the substance class glycol ethers, e.g. ethylene glycol methyl ether, ethylene glycol ethyl ether, ethylene glycol butyl ether, diethylene glycol butylene ether

Test animals

Species:
other: review, several studies
Sex:
not specified
Details on test animals and environmental conditions:
n/a

Administration / exposure

Route of administration:
other: several, data review
Vehicle:
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Glycol ethers and their acetates are readily absorbed following oral administration or inhalation. Dermal absorption is also an important route.
Details on distribution in tissues:
Glycol ethers are readily distributed throughout the body - no substantial accumulation of the parent compound has been observed. In contrast to the metabolites of ethlene glycol methyl ether and ethylene glycol ethyl ether, the metabolite of ethylene glycol butylene ether shows no evidence of significant accumulation.

Any other information on results incl. tables

In the metabolism of the longer chain ethylene glycol ethers (ethylene glycol butyl ether, -propyl ether, -isopropyl ether and -phenyl ether), methoxyacetic and ethoxyacetic acid are not formed.

The alkoxyacetic acid metabolites, methoxyacetic acid and ethoxyacetic acid, have been found to be responsible for bone marrow depression, testicular atrophy, developmental toxicity, and immunotoxicity in animals treated with methyl- and ethyl-substituted ethylene glycol ethers. As these metabolites are not formed in the metabolism of the longer chain ethylene glycol ethers (ethylene glycol butyl ether, -propyl ether, -isopropyl ether and -phenyl ether) these materials do not cause the described effects.

Applicant's summary and conclusion