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Environmental fate & pathways

Henry's Law constant

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Description of key information

The substance will not evaporate into the atmosphere from the water surface.

Key value for chemical safety assessment

Henry's law constant (H) (in Pa m³/mol):
at the temperature of:
25 °C

Additional information


In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. 

According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided. 

For the assessment of 2 -(2 -hexyloxyethoxy)ethanol (Q)SAR results were used for the Henry's law constant. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.



No experimental data are available; therefore, the Henry's Law constant was estimated using the bond estimation method of HENRYWIN v3.20 (EPI Suite v4.11). The substance is not completely within the applicability domain of the model as one bond (C-O) slightly exceeded the maximum number of occurence. As a consequence, the estimate may be slightly less accurate. The HLC was calculated to be 0.000272 Pa*m³/mol. It can be concluded that the substance will not evaporate from the water surface to the atmosphere.