Registration Dossier
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EC number: 203-988-3 | CAS number: 112-59-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Endpoint summary
- Stability
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
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- Biotransformation and kinetics
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Genetic toxicity
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- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): N-hexyldiglykol roh
- Physical state: colourless, fluid
- Analytical purity: not reported
- Batch No.: from continuous production - Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test substance was stirred in M4 medium for about 10 minutes at 20 ± 2°C. The nominal concentration of the stock solution was 100 mg/L. By diluting this stock solution with M4 medium the nominal concentrations were prepared. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: Originally from "Institut National de Recherche Chimique appliquee, France", and has been bred from 1978 in the laboratories of BASF
- Age at study initiation: 2-24 h
- Feeding during test: none
ACCLIMATION
- Acclimation period: none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 2.20 - 3.20 mmol/ L
- Test temperature:
- 19.5 - 20.9 °C
- pH:
- 8.0 - 8.1
- Dissolved oxygen:
- 8.3 - 8.7 mg/L
- Nominal and measured concentrations:
- - Nominal test concentrations: 0, 12.5, 25, 50, 100 mg/L
- Analytical concentrations: < 5, 13, n.m., n.m., 94 mg/L
n.m = not measured - Details on test conditions:
- TEST SYSTEM
- Test vessel: Test tubes (glass) with flat bottom (nominal volume 20 mL)
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 0.5
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: A synthetic fresh water was used for culture and test purposes. This water was prepared on the basis of an
ultrapure, demineralized water with a conductivity < 0 .05 µS/cm. For the composition of this M4 medium see ISO 10706.
- Alkalinity: 0.80 - 1.00 mmol/L
- Ca/Mg ratio: 4:1
- Conductivity: 650 µS/cm
- Intervals of water quality measurement: once at start of experiment
OTHER TEST CONDITIONS
- Photoperiod: 16:8 day-night regime
- Light intensity: About 2- 7 µE/(m²*s) at a wave length of 400 - 700 nm
EFFECT PARAMETERS MEASURED:
- mobility after 0, 3, 6, 24 and 48 h - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Reference
ADDITIONAL REPORTED EFFECT CONCENTRATIONS
- 48 -h EC0: ≥100 mg/L
- 48 -h EC100: >100 mg/L
Description of key information
DGHE is with high probability acutely not harmful to aquatic invertebrates.
The 48-h EC50 value is >100 mg/L in aquatic invertebrates Daphnia magna.
Key value for chemical safety assessment
Additional information
The acute toxicity to aquatic invertebrates was determined in a study according to OECD TG 202 and in compliance with GLP criteria (BASFSE, 1999). In this study daphnids (D. magna, 5 per concentration) were exposed to nominal concentrations of 0, 12.5, 25, 50, 100 mg/L for 48 hours. The two lowest and the highest concentration were analytically verified and remained within ±20%. Therefore, effect concentrations are expressed as nominal. Immobilization was recorded after 48 hours exposure. No immobilization was observed in any of the test concentrations. Based on these findings the 48 -h EC50 value was determined at >100.0 mg/L.
This result is supported by another study performed also according to OECD TG 202 (UCC/Dow, 1999). In this study daphnids (D. magna, 5 per concentration) were exposed to an unspecified range of test concentrations for 48 hours under static conditions. Immobilization was recorded after 48 hours exposure. The 48-h LC50 in this study was determined at 370 mg/L (95% C.I. 330 - 420 mg/L).
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