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EC number: 203-988-3 | CAS number: 112-59-4
Dermal irritation occurred at the application site.
In a well conducted single generation fertility study, 2 -(2 -butoxyethoxy)ethanol produced no signs of toxicity to reproduction in either male or female rats when tested with a dermally dose of 2000mg/kg bw/day. The only finding that was dermal irritation resulting from repeated application of the test substance to the same application site.
Not toxic to reproduction
Females appeared to be more susceptible than males to concentration-dependent irritation at the application site. Effects at the highest dosage were desquamation, atonia, eschar and necrosis.
In a well conducted study designed to assess the sub-chronic and reproductive toxicity of 2 -(2 -butoxyethoxy)ethanol to rats, the test substance was administered by the dermal route for 13 weeks to the maximum practical concentration attainable of 2ml/kg. The only effect of note was dermal irritation at the site of repeated application which occured at all doses, albeit very slight at the low dose and only in males at towards the end of the study. Irritancy was more marked in females than males and produced some necrosis at the highest dose. There were no other adverse findings noted.
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