Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-988-3
CAS number: 112-59-4
For 2 -(2 -hexyloxyethoxy)ethanol Koc values
were calculated to be ca. 10 L/kg (log Koc = 1) and 18.74 L/kg (log Koc
= ca. 1.28) when based on the MCI method and the log Kow method,
respectively. The value of 18.74 L/kg is used for calculation of PNECs
for sediments and soil (based on equilibrium partitioning method (EPM)).
Based on a log Koc of <3 adsorption to solid
soil phase is not expected.
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 2 -(2 -hexyloxyethoxy)ethanol (Q)SAR results were used for adsorption / desorption. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
According to Regulation (EC) No 1907/2006, Annex VIII, Section 9.3.1, Column 2, the study on adsorption/desorption screening does not need to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient), or the substance and its relevant degradation products decompose rapidly.
The substance is readily biodegradable according to OECD criteria (> 90% in 15 d, BASF AG, 1999, report no. 98/0899/21/1; see IUCLID Ch. 5.2.1). In addition, the substance has a log Kow of 1.7 (see IUCLID Ch. 4.7). Therefore, a study does not need to be conducted.
In order to assess the adsorption potential of the substance, the Koc value was estimated using QSAR models. According to the MCI method of the KOCWIN v2.00 module of EPI Suite v4.11 the substance has a log Koc of 1.27 (Koc = 18.7 L/kg). The MCI module is more reliable than the log Kow method of KOCWIN v2.00, which estimates the Koc based on the n-octanol/water partition coefficient. The latter method resulted in a log Koc of 1 (Koc = 10 L/kg). The substance is within the applicability domain of the estimation models.
Based on the estimated adsorption coefficient it can be concluded that adsorption to the solid soil is not to be expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again