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EC number: 930-010-9 | CAS number: 461432-25-7
A key study was completed for acute oral toxicity according to OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method) and EU Method b.1 tris (Acute Oral Toxicity - Acute Toxic Class Method). A key study was also completed for the acute dermal toxicity according to OECD Guideline 402 (Acute Dermal Toxicity), EU Method B.3 (Acute Dermal Toxicity), EPA OPPTS 870.1200 (Acute Dermal Toxicity), and Japanese Ministry of Agriculture, Forestry and Fisheries (JMAFF), 12 Nousan, Notification No 8147, November 2000; including the most recent partial revisions. Both of these studies were completed under GLP. An acute inhalation study was waived as exposure to humans via inhalation is not likely due to the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles, or droplets of inhalable size (exposure considerations).
BMS-587172 -01 was tested in an acute dermal toxicity study with rats, performed according to OECD 402 test guideline and GLP principles. No mortality occurred. Hunched posture (three males and three females) and/or chromodacryorrhoea (four males and one female) were noted between Days 1 and 3. Pelvic dilation of the right kidney was found in one male animal, at macroscopic post mortem examination. Since this is occasionally seen among rats of this age and strain and it was found in one animal only, this was considered not toxicologically significant. Macroscopic examination of the other animals did not reveal any abnormalities.
Based on the rsults of this study, the dermal LD50 value of BMS-587172-01 in Wistar rats was established to exceed 2000 mg/kg body weight.
The acute oral median lethal dose (LD50) of the test material in the Sprague-Dawley CD strain rat was estimated as being greater than 2000 mg/kg bodyweight. The dermal LD50 value in Wistar rats was established to exceed 2000 mg/kg body weight. Therefore, the substance is not classified according to the EU CLP regulation.
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