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Environmental fate & pathways

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BMS 587172 -01 is not readily biodegradable as the material attained 14% degradation after 28 days in the CO2 evolution test.

Hydrolysis as a function of pH of the substance could not be determined due to the low water solubility of the substanceof 11.2 µg/L. It is confirmed in the OECD 111 and EC C.7 guidelines that the hydrolysis study may be difficult to conduct with substances of minimal solubility in water. The study was performed at a concentration half the water solubility.There is no analytical method available that is sensitive enough for quantification of the hydrolysis samples as the hydrolysis study was therefore performed at a nominal concentration of 5.61 µg/L. The concentrations were determined using an analytical method that was not sensitive enough to determine the concentations of the hydrolysis samples accurately. The Tier 1 results should be regarded as indicative. A Tier 2 study was therefore not conducted.

The following indicative results were obtained from the preliminary test: decrease in concentration of > 10% at pH 7 and pH 9 after 5 days and an increase in concentration after 5 days at pH 4. This is below the LOQ of the analytical method (0.1 mg/L in water).

The log Koc was determined to be 5.15 (Koc= 1.4E05).

Additional information