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Density

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Reference
Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
The study was conducted between 18 June 2014 and 22 August 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
pycnometer method
Type:
density
Density:
1 300 kg/m³
Temp.:
23 °C
Type:
relative density
Density:
1.3
Temp.:
23 °C

Calibration

The pressure readings and the calculated volume for the reference and sample cells are shown in the following table:

Determination P1 (psig) P2 (psig) P3 (psig) P4 (psig) Reference Cell Volume (cm3) Sample Cell Volume (cm3)
1 17.337 6.561 17.699 8.764 90.796 149.127
2 17.744 6.713 18.06 8.943 90.672 148.996
3 18.492 6.997 17.5 8.664 90.786 149.147

Mean reference cell volume : 90.752 cm3

Mean sample cell volume : 149.090 cm3

As the reference cell volume and sample cell volume were within the defined tolerance (90.953 ± 1.0 cm3 and 149.225 ± 1.0 cm3 for the reference and sample cell volumes respectively) the gas comparison pycnometer was therefore considered acceptable for use.

Sample

The pressure readings, calculated volumes and density values obtained for the test item are shown in the following table:

Determination Test P1(sample) (psig) P2(sample) (psig) Volume (cm3) Density (kg/m3) Mean Density (kg/m3)
1 A 17.436 6.837 8.403 1.30 x 103 1.30 x 103
B 16.954 6.648 8.403 1.30 x 103
C 18.273 7.165 8.397 1.30 x 103
2 A 18.12 7.085 7.743 1.28 x 103 1.29 x 103
B 17.859 6.981 7.678 1.29 x 103
C 18.022 7.043 7.622 1.30 x 103

Mean density : 1.30 x 103 kg/m3

Relative density : 1.30

Temperature : 23.0 ± 0.5 °C

Discussion

The mass density of a substance varies with temperature and pressure and this variance is typically negligible for solids. Increasing the temperature of a substance may decrease its density by increasing the volume of that substance. Typical thermal expansion coefficients of solids are in the order of 10-5 °C-1, and the volumetric expansion of stainless steel (used as calibration spheres) at 20 °C is approximately 5.2 x 10-5 °C-1.

Therefore, a change in temperature of several degrees will have no significant effect on the volume and hence the density of a solid substance. Therefore, it was considered that the difference in temperature between 20.0 °C and normal laboratory conditions did not have a significant effect on the determined density and therefore the calculated relative density.

Conclusions:
The density of the test item has been determined to be 1.30 x 10³ kg/m³ at 23.0 ± 0.5 °C, relative density 1.30.
Executive summary:

The general physico-chemical properties of BMS-587172-01 have been determined. The results are summarized below:

Density

1.30 x 103 kg/m3 at 23.0 ± 0.5 °C, relative density 1.30, using a gas comparison pycnometer method, designed to be compatible with Method A3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.

The density of the test item has been determined to be 1.30 x 10³ kg/m³ at 23.0 ± 0.5 °C, relative density 1.30.

Description of key information

The density of the test item has been determined to be 1.30 x 10³ kg/m³ at 23.0 ± 0.5 °C, relative density 1.30.

Key value for chemical safety assessment

Relative density at 20C:
1.3

Additional information

The determination was carried with a gas comparison pycnometer, using a procedure designed to be compatible with Method A3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.