Registration Dossier
Registration Dossier
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EC number: 451-530-8 | CAS number: 736150-63-3
Endpoint summary
Administrative data
Description of key information
Additional information
The potential terrestrial toxicity of TS-ED 532 was tested in a number of studies using earthworm, plants and birds.
TS-ED 532 was tested for acute toxic effects on the earthworm Eisenia fetida. Earthworms were exposed for 14 days to TS-ED 532 at a nominal concentration of 1000 mg/kg soil dry weight in a limit test. No mortality was seen during the 14-day exposure to the tested concentration, and the LC50 (14d) was therefore estimated to be > 1000 mg/kg soil dw, based on nominal concentration.
TS-ED 532 was tested for toxic effects on terrestrial plants i.e. the monocotyledon spring barley, Hordeum vulgare, the dicotyledons oil seed rape, Brassica napus and the tomato, Lycopersicon esculentum. The endpoints measured include % emergence, shoot- and root-length for the range-finding test, and % emergence, survival and shoot biomass (dry weight) for the definitive tests. LOEC was 250 mg/kg (nominal) for rape and tomato and 25 mg/kg (nominal) for barley based on plant dry weight effect. No effects were observed for seed emergence and survival of emerging plants (post emergence). EC50 estimates were between 100 to 200 mg/kg of the initial concentration except for barley where EC50 was 12.5 mg/kg.
The acute oral toxicity (LD50) of TS-ED 532 to birds was tested using the Japanese quail. The LD50 of TS-ED 532 to the Japanese quail was evaluated to be in excess of 2000 mg/kg bodyweight (the highest level tested). The no observed effect level was 2000 mg/kg bw.
Overall, TS-ED 532 did not show toxicity to the terrestrial environment using earthworm, birds and plants. The observed effect in the terrestrial plant test is evaluated to be due to a physical effect rather than a chemical effect. TS-ED 532 is a strongly adsorbing and binding substances. Therefore, soil-dwelling organisms that feed on soil particles (e.g. earthworms) are most relevant test species. Furthermore, TS-ED 532 is not suspected of having specific effects on arthropods. Therefore, terrestrial toxicity testing to arthropods is assessed not to be relevant.
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