Registration Dossier
Registration Dossier
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EC number: 451-530-8 | CAS number: 736150-63-3
Endpoint summary
Administrative data
Description of key information
TS-ED 532 has very low acute toxicity. The acute oral and dermal toxicities of TS-ED 532 is greater than 2000 mg/kg bodyweight and therefore considered to be very low. No acute inhalation toxicity of TS-ED 532 is expected. Absorption via the respiratory system is considered negligible. TS-ED 532 is a non-volatile liquid; the vapour pressure is approximately 5-10x10-8 Pa at room temperature (20-25 °C). Formation of aerosols is not expected.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The acute oral toxicity study of TS-ED 532 has not been performed. Based on the results from a 90-day oral toxicity study, in which a NOAEL of 5000 mg/kg bw was derived, it is concluded that the acute oral toxicity is greater than 2000 mg/kg bw.
The acute dermal toxicity of TS-ED 532 was tested in rats by dermal application. It is concluded that the LD50 for acute dermal toxicity of TS-ED 532 is greater than 2000 mg/kg bw.
The acute inhalation toxicity study of TS-ED 532 has not been performed. The vapour pressure of TS-ED 532 was determined to 1.1x10-7 Pa at 25 °C and 4.8x10-8 Pa at 20 °C. Thus TS-ED 532 is not volatile and absorption via the respiratory system is considered negligible. Inhalation of TS-ED 532 is therefore not the most relevante route of human exposure. Formation of aerosols is not expected.
Overall, TS-ED 532 has very low acute toxicity.
Justification for classification or non-classification
TS-ED 532 has been shown to have very low acute toxicity by the oral and dermal route i.e greater than 2000 mg/kg bw. Absorption via the respiratory system is considered negligible. Based on these result, TS-ED 532 is considered not hazardous and shall not be classified according to GHS and DSD-DPD.
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