Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 224-658-5 | CAS number: 4439-24-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Oxidising properties
Administrative data
Link to relevant study record(s)
- Endpoint:
- oxidising liquids
- Type of information:
- other: Expert assessment
- Adequacy of study:
- key study
- Study period:
- August 21, 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The molecular structure (functionality) and composition of 2-(2-methylpropoxy)ethanol was reviewed in line with relevant regulation in order to determine the oxidising potential of the substance.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The oxidising potential of 2-(2-methylpropoxy)ethanol was estimated based on the molecular structure (functionality) and composition of the material. The REACH Regulation (EC) No. 1907/2006 and the CLP Regulation (EC) No. 1272/2008 were referred to in order to screen for relevant properties within the substance known to react exothermically and cause, or contribute to, the combustion of other material, typically by yielding oxygen.
- GLP compliance:
- no
- Key result
- Sample tested:
- other: Not applicable
- Parameter:
- other: Expert assessment / oxidising properties
- Remarks on result:
- other: 2-(2-Methylpropoxy)ethanol does not have oxidising potential.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- An assessment was undertaken to determine the oxidising potential of 2-(2-methylpropoxy)ethanol. Given a lack of structural features associated with oxidising behaviour, such as halogens, nitrogen, or metals, it has been concluded that the registration substance is not an oxidising agent and does not require classification.
- Executive summary:
The oxidising potential of 2-(2-methylpropoxy)ethanol was reviewed through expert assessment of information and experimental data related to the molecular structure, functionality, and composition of the substance. A screening procedure was employed in line with the REACH Regulation (EC) No. 1907/2006 and the CLP Regulation (EC) No. 1272/2008 in order to identify any exothermic properties of the liquid that may, by yielding oxygen, cause or contribute to the combustion of other material and brand 2-(2-methylpropoxy)ethanol an oxidising agent. Halide-oxygen groups, nitrogen-oxygen groups and some metal-oxygen complexes are functional groups that are typical of oxidising agents. It was determined, however, that the raw materials of 2-(2-methylpropoxy)ethanol do not contain nitrogen, metals, or halogens such as chlorine and fluorine, and these elements are not present in the final product. The oxygen that is present within the substance is also chemically bonded to carbon and hydrogen and, therefore, does not pose any risk of reacting exothermically. It can be concluded that 2-(2-methylpropoxy)ethanol does not have oxidising potential and does not require classification. Further testing is not required under Column II of REACH Annex VII.
Reference
Description of key information
It was determined by expert assessment that 2-(2-methylpropoxy)ethanol does not possess the elements typical of an oxidising agent, and that the oxygen atoms present within the structure are chemically bonded to carbon and hydrogen. Subsequently, it can be concluded that there is not a risk of oxidising behaviour and the registration substance does not require classification as an oxidising agent. Further testing is not needed (Column II, REACH Annex VII).
Key value for chemical safety assessment
- Oxidising properties:
- non oxidising
Additional information
The endpoint conclusion obtained for oxidising potential has been assigned a Klimisch score of 2 (reliable with restrictions) given that it has been determined by assessment of a weight of evidence. It is a key value and is considered to be suitable for the purpose of classification and chemical safety assessment.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
