Registration Dossier
Registration Dossier
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EC number: 224-658-5 | CAS number: 4439-24-1
Explosiveness
Administrative data
Link to relevant study record(s)
- Endpoint:
- explosiveness, other
- Type of information:
- other: Expert assessment
- Adequacy of study:
- key study
- Study period:
- August 21, 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed based on the molecular structure and functionality of 2-(2-methylpropoxy)ethanol in conjunction with relevant regulation.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An assessment was undertaken to determine the explosive potential of 2-(2-methylpropoxy)ethanol and the raw materials required in its manufacture. Experimental data and literature relating to the molecular structure (functionality) of the registration substance was reviewed, where available, in conjunction with relevant REACH Regulation (EC) No. 1907/2006 and CLP Regulation (EC) No. 1272/2008. Particular focus was given to a number of structural motifs that are associated with explosive behaviour (Appendix 6, UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed.).
- GLP compliance:
- no
- Key result
- Test series:
- other: Not applicable
- Method:
- other: Expert assessment of available information
- Parameter:
- other: Molecular structure
- Result:
- result is considered "-" (negative)
- Remarks on result:
- other: 2-(2-Methylpropoxy)ethanol does not possess explosive properties
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 2-(2-Methylpropoxy)ethanol does not possess any chemical functionality that is typically associated with explosive behaviour and, therefore, does not require classification for explosiveness.
- Executive summary:
An assessment was undertaken to determine the explosive potential of 2-(2 -methylpropoxy)ethanol and its raw materials based on their molecular structure (functionality) and a review of available literature and experimental data. A number of structural motifs can be linked to explosive behaviour in organic material, as identified in Appendix 6, UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed. The REACH Regulation (EC) No. 1907/2006, Section 7.11 and CLP Regulation (EC) No. 1272/2008, Section 2.1.4.3 were referred to in order to implement a screening procedure. Structural features commonly associated with explosive behaviour were not identified in 2-(2 -methylpropoxy)ethanol and, therefore, the registration substance is not believed to be explosive. The raw components did not contain halogens, nitrogen, or metals, and these elements were not present in the final product. In addition, oxygen was identified but this was not contained within a chemical group that is considered to be linked with explosiveness. Hazard classification of 2-(2-methylpropoxy)ethanol is subsequently not required and further testing is not necessary (Column II of REACH Annex VII).
Reference
Table 1. Elements that are associated with explosive properties (Appendix 6, UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed.).
| Functional group (examples) | Conclusion |
| C-C unsaturation (acetylenes, acetylides, 1,2-dienes) | Not present |
| C-metal and N-metal (Grignard reagents, organo-lithium compounds) | Not present |
| Contiguous N atoms (azides, aliphatic azo compounds, diazonium salts, hydrazines | Not present |
| Contiguous O atoms (peroxides, ozonides) | Not present |
| N-O (hydroxylamines, nitrates, nitro compounds, nitroso compounds, N-oxides) | Not present |
| N-halogen (chloramines, fluoroamines) | Not present |
| O-halogen (chlorates, perchlorates) | Not present |
Description of key information
An expert assessment was undertaken to review the explosiveness of 2-(2-methylpropoxy)ethanol. As a result of the substance not containing any structural features commonly associated with explosive behaviour, it was concluded that the substance is not an explosive. 2-(2-methylpropoxy)ethanol subsequently does not require classification (CLP Regulation (EC) No. 1272/2008).
Key value for chemical safety assessment
- Explosiveness:
- non explosive
Additional information
The endpoint conclusion determined for explosiveness is believed to be the key value and has been assigned a Klimisch score of 2 (reliable with restrictions) given that it was obtained from a weight of evidence approach.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
