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EC number: 224-658-5
CAS number: 4439-24-1
experiment was undertaken by Tanniet al. (1992) to determine the
octanol-water partition coefficient of 2-(2-methylpropoxy)ethanol and
thirteen other ethylene glycol ethers as part of a study evaluating
structure-toxicity relationships. The estimation (solubility ratio)
methodology followed was according to that outlined by Tanni and
Hashimoto (1982) and involved analyses by gas-liquid chromatography with
flame ionisation detection and a glass column. Under the conditions of
the experiment, 2-(2-methylpropoxy)ethanol was reported to be evidently
separated from the organic (n-octanol) phase that had been
dissolved in water. Following analyses, a log Kow of 0.75 was determined
analyses by gas-liquid chromatography, a log Kow of 0.75 was determined
for the partition coefficient of 2-(2-methylpropoxy)ethanol, i.e. the
ratio of the concentrations of the registered substance present in water
and an organic (n-octanol) phase.
The key value was obtained from a study that
was considered to be well documented and have met generally accepted
scientific principles. The result was published in a reputable
scientific journal (Archives of Toxicology) and the procedure, although
not guideline (e.g. OECD) or a national standard method, was published
by Toxicology Letters (Tanni and Hashimoto 1982). A Klimisch score of 2
(reliable with restrictions) has subsequently been recommended for the
endpoint value and it is suitable for chemical safety assessment.
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