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EC number: 224-658-5 | CAS number: 4439-24-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 12, 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: Tanii and Hashimoto (1982)
- Version / remarks:
- Tanii, H. and Hashimoto, K. (1982). Structure-toxicity relationship of acrylates and methacrylates. Toxicology Letters, 11, 125 - 129.
- Deviations:
- no
- Principles of method if other than guideline:
- N-octanol was saturated with distilled water and distilled water was saturated with n-octanol. The test substance was dissolved in distilled water at <1.0 mM. Within sealed tubes the water and n-octanol organic phase were mixed at a volume ratio of 5 ml and 1.0 ml, respectively, before being placed on a mechanical shaker for 1 hour and centrifuged for 30 minutes at 2500 revolutions per minute. Gas-liquid chromatography (Hitachi Model 163 gas chromatograph with flame ionisation detector) was used to analyse the quantity of 2-(2-methylpropoxy)ethanol in the water phase. The temperature of the gas chromatography glass column and detector was 160 and 180 °C, respectively, and the carrier gas was N2. The column was packed with polyethylene glycol 20 M. The concentration of 2-(2-methylpropoxy)ethanol) in the water phase was used to determine that present inn-octanol. The following equation was used to calculate the partition coefficient for the registered substance:
P = Concentration of ester in-octanol / Concentration of ester in water - GLP compliance:
- no
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: Gas-liquid chromatography (Hitachi Model 163)
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.75
- Remarks on result:
- other: Mean of three determinations / Undertaken at room temperature
- Details on results:
- 2-(2-methylpropoxy)ethanol) was clearly seperated from the organic n-octanol phase that was dissolved in distilled water.
- Conclusions:
- The octanol-water partition coefficient for 2-(2-methylpropoxy)ethanol was calculated to be log Kow = 0.75 following analyses by gas-liquid chromatography.
- Executive summary:
An experiment was undertaken by Tanniet al. (1992) to determine the octanol-water partition coefficient of 2-(2-methylpropoxy)ethanol and thirteen other ethylene glycol ethers as part of a study evaluating structure-toxicity relationships. The estimation (solubility ratio) methodology followed was according to that outlined by Tanni and Hashimoto (1982) and involved analyses by gas-liquid chromatography with flame ionisation detection and a glass column. Under the conditions of the experiment, 2-(2-methylpropoxy)ethanol was reported to be evidently separated from the organic (n-octanol) phase that had been dissolved in water. Following analyses, a log Kow of 0.75 was determined for 2-(2-methylpropoxy)ethanol.
Reference
Description of key information
Following analyses by gas-liquid chromatography, a log Kow of 0.75 was determined for the partition coefficient of 2-(2-methylpropoxy)ethanol, i.e. the ratio of the concentrations of the registered substance present in water and an organic (n-octanol) phase.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.75
- at the temperature of:
- 20 °C
Additional information
The key value was obtained from a study that was considered to be well documented and have met generally accepted scientific principles. The result was published in a reputable scientific journal (Archives of Toxicology) and the procedure, although not guideline (e.g. OECD) or a national standard method, was published by Toxicology Letters (Tanni and Hashimoto 1982). A Klimisch score of 2 (reliable with restrictions) has subsequently been recommended for the endpoint value and it is suitable for chemical safety assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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