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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data from handbook: no guideline or method reported.
GLP compliance:
not specified
Test type:
other: Not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
400 mg/kg bw
Based on:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Based on:
not specified
Other findings:
Hemolysis as evidenced by hemoglobinuria and associated liver and kidney injury

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 values for rats of 400 mg/kg and 1000 mg/kg bw were reported in a toxicology handbook. Both values fall within the classification criteria for Acute Toxicity Category 4 via the oral route in accordance with Regulation (EC) N° 1272/2008.
Executive summary:

Two oral LD50 values for rat from seperate unpublished studies were reported in a scientific handbook. No information on the method was given. The LD50 values of 400 mg/kg bw and 1000 mg/kg bw both fall within the classification criteria for Acute Toxicity Category 4 via the oral route in accordance with Regulation (EC) N° 1272/2008.