Registration Dossier
Registration Dossier
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EC number: 224-658-5 | CAS number: 4439-24-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Data from handbook: no guideline or method reported.
- GLP compliance:
- not specified
- Test type:
- other: Not specified
Test material
- Reference substance name:
- 2-(2-methylpropoxy)ethanol
- EC Number:
- 224-658-5
- EC Name:
- 2-(2-methylpropoxy)ethanol
- Cas Number:
- 4439-24-1
- Molecular formula:
- C6H14O2
- IUPAC Name:
- 2-(2-methylpropoxy)ethan-1-ol
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 400 mg/kg bw
- Based on:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Based on:
- not specified
- Other findings:
- Hemolysis as evidenced by hemoglobinuria and associated liver and kidney injury
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 values for rats of 400 mg/kg and 1000 mg/kg bw were reported in a toxicology handbook. Both values fall within the classification criteria for Acute Toxicity Category 4 via the oral route in accordance with Regulation (EC) N° 1272/2008.
- Executive summary:
Two oral LD50 values for rat from seperate unpublished studies were reported in a scientific handbook. No information on the method was given. The LD50 values of 400 mg/kg bw and 1000 mg/kg bw both fall within the classification criteria for Acute Toxicity Category 4 via the oral route in accordance with Regulation (EC) N° 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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