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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data from handbook: no guideline or method reported.
GLP compliance:
not specified
Test type:
other: Not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-methylpropoxy)ethanol
EC Number:
224-658-5
EC Name:
2-(2-methylpropoxy)ethanol
Cas Number:
4439-24-1
Molecular formula:
C6H14O2
IUPAC Name:
2-(2-methylpropoxy)ethan-1-ol

Test animals

Species:
rat

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
400 mg/kg bw
Based on:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Based on:
not specified
Other findings:
Hemolysis as evidenced by hemoglobinuria and associated liver and kidney injury

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 values for rats of 400 mg/kg and 1000 mg/kg bw were reported in a toxicology handbook. Both values fall within the classification criteria for Acute Toxicity Category 4 via the oral route in accordance with Regulation (EC) N° 1272/2008.
Executive summary:

Two oral LD50 values for rat from seperate unpublished studies were reported in a scientific handbook. No information on the method was given. The LD50 values of 400 mg/kg bw and 1000 mg/kg bw both fall within the classification criteria for Acute Toxicity Category 4 via the oral route in accordance with Regulation (EC) N° 1272/2008.