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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-05-30 to 2017-05-31
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
European Commission Regulations (EC) No. 440/2008 and No. 761/2009
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
Adopted :
23 March 2006
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: Knudsen cell
Specific details on test material used for the study:
Storage conditions: Room temperature (10 °C - 30 °C), dark, dry
Expiry date: April 11, 2018
Certificate: Certificate of analysis No. 28657 dated April 23, 2013
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 Pa
Remarks on result:
other: Calculated based on Antoine constants
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0.001 Pa
Remarks on result:
other: Calculated based on Antoine constants
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
0.002 Pa
Remarks on result:
other: Calculated based on Antoine constants

Individual results

The vapour pressure was measured in the temperature range of 70 °C to 120 °C. The test item contains two main constituents with molecular weights of 469 g/mol and 537 g/mol, respectively.

As a conservative approach a molecular weight of 469 g/mol was used for evaluation. The measured vapour pressures at the corresponding temperatures are listed in the following Table. After the measurement a mass loss of approx. 4 % (w/w) was determined.

Measured vapour pressures and corresponding temperatures:

Temperature / °C

 Vapour pressure / hPa

70

4.4 x 10-5

80

5.4 x 10-5

90

1.1 x 10-4

100

1.6 x 10-4

110

2.0 x 10-4

120

2.2 x 10-4

The vapour pressure curve given below plots the vapour pressure (logarithmic scale) as a function of the inverse temperature (1/T, T in Kelvin). The course of the vapour pressure curve was not linear as might be expected. This was most likely caused by the composition of the test item. Only for better readability the temperature is also reported in a centigrade scale at the top of the plot given below. The values for 20, 25 and 50 °C are calculated, using the Antoine constants A, B and C as shown in the Table below:

T [°C]

p [hPa]

log(p[hPa])= A + B/(C+T[°C])

20

4.0 x 10E-06

A = 1.69496

25

5.3 x 10E-06

B = -2077.87

50

1.8 x 10E-05

C = 273.15

Conclusions:
Vapour pressure (EU method A.4): 4.0E-04 Pa at 20 °C
Executive summary:

The vapour pressure of the test item was determined in a reliable study (RL 1) performed according to EU method A.4 compliant with GLP.

The method applied was vapour pressure balance (effusion method, using a Knudsen cell). Measurements were performed at 6 temperatures (between 70 and 120 °C, interval 10 °C). The course of the vapour pressure curve was not linear as might be expected. This was most likely caused by the composition of the test item. Vapour pressure was extrapolated to lower temperatures using Antoine constants determined from the data.

The following results were obtained:

20°C:       4.0E-04 Pa;

25°C:       5.3E-04 Pa;

50°C:       1.8E-03 Pa.

Description of key information

Vapour pressure (EU method A.4): 4.0E-04 Pa at 20 °C

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information

The vapour pressure of the test item was determined in a reliable study (RL 1) performed according to EU method A.4 compliant with GLP.

The method applied was vapour pressure balance (effusion method, using a Knudsen cell). Measurements were performed at 6 temperatures (between 70 and 120 °C, interval 10 °C). The course of the vapour pressure curve was not linear as might be expected. This was most likely caused by the composition of the test item. Vapour pressure was extrapolated to lower temperatures using Antoine constants determined from the data.

The following results were obtained:

20°C:       4.0E-04 Pa;

25°C:       5.3E-04 Pa;

50°C:       1.8E-03 Pa.

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