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Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June 2017 to Nov. 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
Differential scanning calorimetry is one of the methods applicable for determination of the melting point /melting range according to OECD 102
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
Adopted: 27.07.95
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
European Commission Regulation (EC) No. 440/2008
Deviations:
no
GLP compliance:
no
Type of method:
differential scanning calorimetry
Key result
Melting / freezing pt.:
>= 51.5 - <= 85 °C
Atm. press.:
ca. 1 013 hPa
Decomposition:
no
Sublimation:
no
Remarks on result:
other: endothermic peak of melting range: 76.5 °C

No endothermal effect other than the one referred to as melting (onset 51.50 °C; peak 76.50 °C) was detected up to a temperature of approx. 140 °C.

Details on replicate measurements:

 

Onset temperature [°C]

Peak temperature [°C]

Replicate 1

51.55

76.50

Replicate 2

51.45

76.50

Arithmetic mean value

51.50

76.50

Conclusions:
Melting range (OECD 102; DSC): 51.50 °C to ca. 85°C; endothermic melting range peak: 76.5 °C
Executive summary:

The melting range for the test item was determined in a reliable study using differential scanning calorimetry according to relevant guidelines (OECD 102; EU method A.1).

Based on the Indium standard, an accuracy of the measurement of 99.94% was determined.

Two replicate heating-cooling-heating experiments were performed between 25°C and 140 °C (heating rate: 10.00 K/min; cooling rate -2.00 K/min). The second heating step was used to determine the melting range. The following results were obtained at ambient pressure (ca. 1013 hPa; arithmetic mean of 2 replicate determinations):

Onset: 51.50 °C (single measurements: 51.55 °C; 51.45 °C);

Peak: 76.50 °C (single measurements identical);

Offset: ca. 85 °C

Description of key information

Melting range (OECD 102; DSC) at ambient pressure (ca. 1013 hPa): 51.50 °C to ca. 85°C; endothermic melting range peak: 76.5 °C

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
51.5 °C

Additional information

The melting range for the test item was determined in a reliable study using differential scanning calorimetry according to relevant guidelines (OECD 102; EU method A.1).

Based on the Indium standard, an accuracy of the measurement of 99.94% was determined.

Two replicate heating-cooling-heating experiments were performed between 25°C and 140 °C (heating rate: 10.00 K/min; cooling rate -2.00 K/min). The second heating step was used to determine the melting range. The following results were obtained at ambient pressure (ca. 1013 hPa; arithmetic mean of 2 replicate determinations):

Onset: 51.50 °C (single measurements: 51.55 °C; 51.45 °C);

Peak: 76.50 °C (single measurements identical);

Offset: ca. 85 °C