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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-03-06 to 2017-08-02
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
other: ISO 13322-2
Version / remarks:
2006-11-01
Deviations:
no
GLP compliance:
no
Type of method:
other: Dynamic image analysis
Type of particle tested:
primary particle
Type of distribution:
mass based distribution
Mass median aerodynamic diameter:
105.76 µm
Remarks on result:
other: Because of a density near 1 g/cm^3 (0.9924), the mass median diameter is essentially equal to the mass median aerodynamic diameter
No.:
#1
Size:
<= 45.39 µm
Distribution:
10 %
No.:
#2
Size:
<= 105.76 µm
Distribution:
50 %
No.:
#3
Size:
<= 210.57 µm
Distribution:
90 %
No.:
#4
Size:
<= 547.83 µm
Distribution:
99 %

In total, 1,294,464 particles were measured via dynamic image analysis. Size of particles was calculated by EQPC (Circle of Equal Projection Area).

Q3(x) is the volume distribution with the length parameter x. As the length parameter EQPC was used.

Sauter mean diameter: 83.52 µm;

Volume mean diameter: 125.09 µm;

Particle size

125.00 µm

Q3=61.41%

residual =38.59%

Particle size

250.00 µm

Q3=94.53%

residual =5.47%

Particle size

500.00 µm

Q3=98.77%

residual =1.23%

Results table:

Interval-upper limit

x0/µm

Distribution sum

Q3/%

residual

(1-Q3)/%

Fraction dQ3/%

center of interval xm/µm

Density distribution

q3lg

11.28

0.15

99.85

0.15

7.98

0.01

12.15

0.20

99.80

0.05

11.71

0.01

14.75

0.34

99.66

0.14

13.39

0.02

17.92

0.58

99.42

0.23

16.26

0.03

21.76

1.01

98.99

0.43

19.75

0.05

26.43

1.79

98.21

0.78

23.98

0.09

32.10

3.25

96.75

1.47

29.13

0.17

38.99

6.29

93.71

3.04

35.38

0.36

47.36

11.14

88.86

4.85

42.97

0.57

57.52

17.47

82.53

6.33

52.19

0.75

69.86

25.92

74.08

8.45

63.39

1.00

84.86

36.10

63.90

10.18

77.00

1.21

103.06

48.40

51.60

12.30

93.52

1.46

125.18

61.52

38.48

13.12

113.58

1.55

152.04

74.46

25.54

12.95

137.96

1.53

184.66

85.26

14.74

10.79

167.56

1.28

224.29

92.51

7.49

7.25

203.51

0.86

272.41

96.29

3.71

3.78

247.18

0.45

330.87

98.01

1.99

1.72

300.22

0.20

401.86

98.39

1.61

0.38

364.64

0.04

488.09

98.71

1.29

0.32

442.88

0.04

592.83

99.22

0.78

0.50

537.92

0.06

720.03

99.42

0.58

0.20

653.34

0.02

874.54

99.42

0.58

0.00

793.53

0.00

1062.19

100.00

0.00

0.58

963.81

0.07

1290.12

100.00

0.00

0.00

1170.62

0.00

1566.95

100.00

0.00

0.00

1421.81

0.00

1903.18

100.00

0.00

0.00

1726.90

0.00

2311.55

100.00

0.00

0.00

2097.45

0.00

2807.56

100.00

0.00

0.00

2547.51

0.00

3410.00

100.00

0.00

0.00

3094.15

0.00

3653.89

100.00

0.00

0.00

3529.84

0.00

Conclusions:
Mass median diameter (dynamic image analysis; ISO 13322-2): 105.76 µm
Executive summary:

Particle size distribution for the test item was determined using dynamic image analysis according to ISO 13322 -2 (Voelpker, 2017).

In total, 1,294,464 particles were measured via dynamic image analysis. Size of particles was calculated by EQPC (Circle of Equal Projection Area).

The following results had been determined:

Sauter mean diameter: 83.52 µm;

Volume mean diameter: 125.09 µm;

Mass median diameter: 105.76 µm

D 10 (mass) diameter: 45.39 µm;

D 90 (mass) diameter: 210.57 µm.

Description of key information

Mass median diameter (dynamic image analysis; ISO 13322-2): 105.76 µm

Additional information

Particle size distribution for the test item was determined using dynamic image analysis according to ISO 13322 -2 (Voelpker, 2017).

In total, 1,294,464 particles were measured via dynamic image analysis. Size of particles was calculated by EQPC (Circle of Equal Projection Area).

The following results had been determined:

Sauter mean diameter: 83.52 µm;

Volume mean diameter: 125.09 µm;

Mass median diameter: 105.76 µm

D 10 (mass) diameter: 45.39 µm;

D 90 (mass) diameter: 210.57 µm.