Registration Dossier
Registration Dossier
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EC number: 944-188-0 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: little details reported, few animals, low maximal dose
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
- Principles of method if other than guideline:
- Animals were injected 500 or 3000 µM Fe/kg bw (28 or 168 mg Fe/kg) and observed for 14 days. Control animals were sham-treated. Parameters: Mortality, observation, body weight, food consumption, necropsy
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Triiron tetraoxide
- EC Number:
- 215-277-5
- EC Name:
- Triiron tetraoxide
- Cas Number:
- 1317-61-9
- Molecular formula:
- Fe3O4
- IUPAC Name:
- Triiron tetraoxide
- Details on test material:
- Superparamagnetic iron oxide provided as an aqueous colloid with a concentration of 200 µM Fe/ml (11.2 mg/ml). The volume median diameter of particles was 80 nm (no data on composition or purity).
AMI 25 = superparamagnetic iron oxide provided as an aqueous colloid with a concentration of 200 µM Fe/ml (11.2 mg/ml). The volume median diameter of particles was 80 nm.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Doses:
- 500 - 3000 µM Fe/ kg bw (28 - 168 mg Fe/kg bw)
- No. of animals per sex per dose:
- 18
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 168 mg/kg bw
Any other information on results incl. tables
Mortality: none
Body weight: no effect
Food consumption: no effect
Observation: no effects
Necropsy: no findings reported
Applicant's summary and conclusion
- Conclusions:
- No standard test method - no mortality occured, real LD50 probably much higher than maximum applied dose
- Executive summary:
- Animals were injected 500 or 3000 µM Fe/kg bw (28 or 168 mg Fe/kg) and observed
for 14 days. No toxic effects were obseved.
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