Registration Dossier
Registration Dossier
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EC number: 944-188-0 | CAS number: -
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: not relevant - coated iron oxides were used in the studies
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
- Study type:
- clinical case study
- Principles of method if other than guideline:
- Superparamagnetic particles were used as contrast medium in MRI (Magnetic Resonance Imaging)
Test material
- Reference substance name:
- Triiron tetraoxide
- EC Number:
- 215-277-5
- EC Name:
- Triiron tetraoxide
- Cas Number:
- 1317-61-9
- Molecular formula:
- Fe3O4
- IUPAC Name:
- Triiron tetraoxide
- Details on test material:
- Lönnemark et al. used polymeric particles coated with magnetite (Fe3O4) and gamma Fe2O3
Magin et al. used dextran coated iron oxide (magnetite)
Constituent 1
Method
- Subjects:
- Humans and laboratory animals (rats)
- Reason of exposure:
- other: as contrast medium in MRI
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Magnetic iron oxides demonstrated a significantly increase in dectability of some
abdominal tumors by MR
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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