Registration Dossier
Registration Dossier
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EC number: 944-188-0 | CAS number: -
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: short abstract, original in Russian; few details
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
- Principles of method if other than guideline:
- Application of magnetite as a 50% suspension in sunflower oil
- GLP compliance:
- no
Test material
- Reference substance name:
- Triiron tetraoxide
- EC Number:
- 215-277-5
- EC Name:
- Triiron tetraoxide
- Cas Number:
- 1317-61-9
- Molecular formula:
- Fe3O4
- IUPAC Name:
- Triiron tetraoxide
- Details on test material:
- Test substance: Magnetite (no data on purity)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sunflower oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6 weeks
- Frequency of treatment:
- weekly
Doses / concentrations
- Remarks:
- Doses / Concentrations:
20000 mg/kg
Basis:
no data
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levels
- Dose descriptor:
- other:
- Effect level:
- 20 000 other: mg/kg bw/weekly
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: No differences between treated and control group.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Treatment did not cause any effects on blood, urine, body temperature, weight, heart rate.
Applicant's summary and conclusion
- Executive summary:
Rats received into the stomach once a week for seven times 20000 mg/kg of test substance.
No differences between treated and control group.
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