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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
cytotoxicity
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The composition of the test substance (iron ore) is unknown

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1995

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Iron ore dust (not further specified)

Results and discussion

Details on results:
Cytotoxicity of iron ore dust was related to the lipid peroxidation

Any other information on results incl. tables

Phagocytic activity of alveolar macrophages on S. cerevisiae was depressed, LDH activity 
was increased, and potassium concentration in the  cells was reduced. Cells were 
morphologically not damaged, but lipid  peroxidation was increased.

Applicant's summary and conclusion

Executive summary:

Cytotoxicity of iron ore dust was related to the lipid peroxidation