Registration Dossier

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: short report - original language Russian
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1976

Materials and methods

Principles of method if other than guideline:
Type: reproduction in the course of a chronic toxicity study
Method: application of magnetite as a 50% suspension in sunflower oil
GLP compliance:
no
Type of method:
in vivo

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: Magnetite (no data on purity)

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sunflower oil
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
6 weeks
Frequency of treatment:
weekly
Doses / concentrations
Remarks:
Doses / Concentrations:
20 000 mg/kg
Basis:

Control animals:
yes

Results and discussion

Effect levels

Dose descriptor:
other: reproduction in the course of a chronic toxicity study
Effect level:
> 20 000 other: mg/kg bw/weekly
Based on:
test mat.
Basis for effect level:
other: No effects of the treatment were detected regarding number and development of offspring

Observed effects

negative

Applicant's summary and conclusion

Executive summary:
No effects of the treatment were detected regarding number and development of offspring