1-chloro-4-nitrobenzene

Bioaccumulation: aquatic / sediment

Administrative data

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Unsuitable test system (more than one substance tested in the same vessel). BCF for p-chloronitrobenzene cannot be derived with this test design; adopted according to OECD SIDS. The original source is available and has been reviewed.

Data source

Reference

Reference 1

Title:

No information

Author:

Niimi, A.J. et al., Octanol/water partition coefficients and bioconcentration factors of chloronitrobenzenes in rainbow trout (salmo gairdneri). Environmental Toxicology and Chemistry 8, 817-823 (1989)

Reference 2

Reference Type:

secondary source

Title:

1-chloro-4-nitrobenzene

Author:

OECD SIDS

Year:

2002

Bibliographic source:

SIDS Initial Assessment Report for SIAM 15, UNEP Publications

Materials and methods

Principles of method if other than guideline:

Method: other: 30 fish exposed to 780+/-130 ng TS/l in a flow-through system; aceton used as solvent; samples of 6 fish each analysed at 5,12,20,28 and 36 days of exposure; duplicate water samples taken every 3 or 4 days; GC analysis

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Automatically generated during migration to IUCLID 6, no data available

IUPAC Name:

Automatically generated during migration to IUCLID 6, no data available

Details on test material:

Test substance: other TS: mono- to pentachloronitrobenzenes

Test organisms

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Total exposure / uptake duration:

36 d

Test conditions

Test temperature:

15 °C

Nominal and measured concentrations:

0.78 µg/l

Results and discussion

Bioaccumulation factor

Type:

BCF

Value:

84 - 112

Any other information on results incl. tables

The BCF were determined for 5 incubation periods: 84 +/- 8 for 5 days, 112 +/- 23 for 12 days, 96 +/- 14 for 20 days, 103 +/- 16 for 28 days, and 108 +/- 15 for 36 days. The mean BCF was 101 +/- 18 with significant differences (p </= 0.05) among the sample intervalls. Since the higher chlorinated nitrobenzenes are possibly dechlorinated by metabolism in fish, a BCF for p-chloronitrobenzene cannot be derived with this test design.