1-chloro-4-nitrobenzene

Endpoint summary

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (sensitising)

Additional information:

In an acceptable, well-documented publication which meets basic scientific principles the skin sensitisation potential of 1 -chloro-2 -nitrobenzene was investigated. The study was performed in guinea pigs with 3 drops of a 10% solution to a clipped area of the skin. On the 22nd day Freund-adjuvans was injected with the test substance into the hind paw (0.5 mg/kg bw). 28 days after the first administration 3 drops of the 10 % solution were applied to an untreated clipped area of the skin. The test substance induce sensitisation reactions in 50% of the tested animals.There is sufficient evidence that 1 -chloro-4 -nitrobenzene has a sensitisation potential (Rusakov et al., 1973).

A further indicator to a sensitisation potential of 1 -chloro-4 –nitrobenzene is the comparable chemical structure to the typical sensitizer 2,4-dinitrochlorobenzene. The allergenic activity of p-chloronitrobenzene is less marked than that of 2,4-dinitrochlorobenzene but p-chloronitrobenzene provokes stronger sensitiation effects than o-chloronitrobenzene.

Migrated from Short description of key information:
p-chloronitrobenzene was found to be a sensitizer

Justification for classification or non-classification

Classification:

DSD: Xi, R43. May cause sensitisation by skin contact.

EU-GHS: Skin Sensitisation Category 1. May cause an allergic skin reaction.