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EC number: 202-809-6 | CAS number: 100-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
P-chloronitrobenzene was found to be harmful if swallowed, in contact with skin and by inhalation.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 294 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- discriminating conc.
- Value:
- 16 100 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 750 mg/kg bw
Additional information
p-chloronitrobenzene is toxic by oral administration, dermal contact and by inhalation.
The acute oral toxicity of 1 -chloro-4 -nitrobenzene was investigated in male Wistar II rats in a study comparable to OECD
guideline 401 with acceptable restrictions. 7 male groups of 10 animals were dosed with 100, 200, 300, 350, 400, 500 and 600 mg/kg bw 1-chloro-4-nitrobenzene per gavage and observed for 14 days following exposure for mortality and clinical signs. Mortalities occurred at dose levels equal to and exceeding 200 mg/kg bw 2 days after administration. Reduced general condition, cyanotic appearance, diarrhea, increased excretion of urine were observed in all male animals dosed 200 - 600 mg/kg bw. Symptoms started to appear between 3 hours (600 mg/kg bw) and 4 days (400 and 600 mg/kg bw) after administration. No clinical signs were observed in animals dosed with 100 mg/kg bw in male rats. The calculated LD50 for male rats was 294 mg/kg bw.The dermal LD50 ranges for rats are between 750 - 1722 mg/kg body weight and the ranges in rabbit studies are between 2000 - 3160 mg/kg bw.
In a study performed comparable to guideline study 402 with acceptable restrictions the acute dermal toxicity of 1 -chloro-4 -nitrobenzene was investigated in male rats. The LD50 was 750 mg/kg body weight (Loeser, Bayer AG, 1979).
The acute inhalative toxicity of 1 -chloro-4 -nitrobenzene was investigated in study comparable to OECD guideline 403 with acceptable restrictions. Rats were exposed head-only to an atmosphere containing vapour and microcrystalline particles up to 16,100 mg/m³ air for 4 hours. Clinical signs of toxicity were related to dose. During and immediately after exposure cyanosis, corneal opacity, abnormal arched-back posture, lethargy, reddish-brown nasal and frothy mouth discharges, tachypnea, semi-prostration were observed. From 1 - 14 days post exposure pallor, lacrimation, alopecia, corneal opacity, stained perineal area, dermal irritations were observed. Aslo weight loss of 6 - 13 % was detected within the first 24 hours but weight gain normailzed therafter. Three days post exposure death occured at 16100 mg/m³ in 1 of 10 animals. Therefore the LCLo was 16100 mg/m³air (Dupont, 1981).
Justification for classification or non-classification
Based on the available study results, the following classification is derived; this deviates from the present legal classification (see Section 2):
LD50(oral) = 294 mg/kg bw
Classification:
DSD: Xn, R22 Harmful if swallowed
GHS: Acute Oral Category 3 H301
LD50(dermal) = 750 mg/kg bw
Classification:
DSD: Xn, R21 Harmful in contact with skin
GHS: Acute Dermal Category 3 H311
LCLo (inhalation) = 16100 mg/m3 air
Classification:
DSD: Xn, R20 Harmful by inhalation
GHS: Acute Inhalation Category 3 H331
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