Registration Dossier
Registration Dossier
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EC number: 202-809-6 | CAS number: 100-00-5
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Title:
- No information
- Author:
- Li Q, Minami M, Hanaoka T, Yamamura Y (1999) Acute|immunotoxicity of p-chloronitrobenzene in mice: II. Effect|of p-chloronitrobenzene on the immunophenotype of murine|splenocytes determined by flow cytometry. Toxicology 137:|35-45 (1999)
Materials and methods
- Principles of method if other than guideline:
- other: see remark
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: BDF1
- Sex:
- male
Administration / exposure
- Route of administration:
- other: i.p. or s.c.
- Vehicle:
- other: olive oil
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 300 mg/kg bw
Basis:
- No. of animals per sex per dose:
- 24
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Type: other
Observation period: up to 10 days
Results and discussion
Any other information on results incl. tables
Spleen weight sign. greater in exposed animals
Indication of immunotoxic effect: Reduction of natural
killer cells, T cells and B cells in the spleen, and
increase in macrophages and nucleated erythrocythes and dead
cells (after i.p.) in the spleen
comparison of i.p. and s.c. application: sign. difference in
macrophages and nucleated erythrocytes, i.p. more
macrophages, s.c. more nucleated erythrocytes
Applicant's summary and conclusion
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