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Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP - guideline study

Data source

Referenceopen allclose all

Title:
No information
Author:
Chou BJ, Leach CL, Miller RA, Horstman MG, Ragan HA, Bucher|JR, Roycroft JH (1991) 13-week subchronic inhalation|toxicity of 4-chloronitrobenzene (4-DCB) in rodents. The|Toxicologist 11: 87 Abstr. 262
Title:
No information
Author:
NTP (1993) 2-Chloronitrobenene and 4-Chloronitrobenzene:|Administered by inhalation to F344/N rats and B6C3F1 mice.|Toxicity Report Series No. 33, NIH Publication, 93-3382,|July/1993

Materials and methods

Principles of method if other than guideline:
Type: other: subchronic
Method: other: 10 rats/sex/group of the 0,6, 12, 24 ppm groups, whole body exposure, f: necropsy bw, estrous cycle length, percent of cycle spent in the various stages; m: necropy bw, reproduct. tissue weights, spermatozoal data, spermatogenes
GLP compliance:
yes
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloro-4-nitrobenzene
EC Number:
202-809-6
EC Name:
1-chloro-4-nitrobenzene
Cas Number:
100-00-5
Molecular formula:
C6H4ClNO2
IUPAC Name:
1-chloro-4-nitrobenzene
Details on test material:
- Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: 98.8 %

Test animals

Species:
rat
Strain:
other: F344/N
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
13 w
Frequency of treatment:
6 h/d, 5 d/w
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 1.5, 3, 6, 12, or 24 ppm (= ca. 0.0, 9.81, 19.62, 39.24, 78.48,or 156.96 mg/m³ air)
Basis:

Control animals:
yes, concurrent vehicle
Details on study design:
Duration of test: 13 w

Results and discussion

Observed effects

see freetext RS

Any other information on results incl. tables

6, 12 and 24 ppm: among females, average estrous cycle
length significantly decreased
24 ppm: among males, left caudal epididymal and
testicular weights, epididymal sperm (spermatozoa) count per
gram of caudal tissue and total spermatid head count per
testis significantly decreased

Applicant's summary and conclusion

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