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Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
LOAEL
3 mg/kg bw/day

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Dose descriptor:
LOAEC
9.81 mg/m³

Additional information

Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: other

Repeated dose toxicity: inhalation - systemic effects (target organ) cardiovascular / hematological: other

Justification for classification or non-classification

The LOAEC for effects on red blood cells (MetHb formation, haemosiderosis) is 9.81 mg/m³, similar effects were seen after oral dosing at 3 mg/kg bw/day. This justifies classification as STOT RE Cat 1. However, the existing legal classification deviates from this finding and is given in Section 2.

Under DSD, T-R48/23/25 is the appropriate classification based on the available data. However, the existing legal classification is deviant from this finding and is given in Section 2.

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