Sodium O-isobutyl dithiocarbonate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

Severe effects seen in three rabbits.  Study terminated after 3 days for humane reasons

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

no

Principles of method if other than guideline:

Severe effects seen in three rabbits.  Study terminated after 3 days for humane reasons

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium isobutyl xanthate

IUPAC Name:

Sodium isobutyl xanthate

Test material form:

solid - liquid: suspension

Details on test material:

- Physical state: orangee liquid- Analytical purity: 456,1g/dm3- ph=10.1

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

Age: 4 monthWeight: 2.9 kg

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

water

Amount / concentration applied:

0,5 ml of water solution pH=10, containing 456,1g/dm3 of SIX, on 2,5x25cm of shaved skin

Duration of treatment / exposure:

4 hours exposure

Observation period:

1; 24; 48 and 72 h

Number of animals:

3 male

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

edema score

Basis:

mean

Time point:

24/48/72 h

Score:

3

Max. score:

3

Reversibility:

not fully reversible within: 72 hours

Remarks on result:

other: Terminated at 72 hours

Results 2

Irritation parameter:

erythema score

Basis:

mean

Time point:

72 h

Score:

4

Max. score:

4

Reversibility:

not fully reversible within: 72 hours.

Remarks on result:

other: Terminated at 72 hours

Irritant / corrosive response data:

observation after 1h – bloody effusions, moderate swelling, oedema, after 24 ,48 and 72h – tinea on the exposition place and around redness, oedema.

Any other information on results incl. tables

	Animal nr	1 24 48 72
erythema	1	4 4 4 4
	2	4 - - -
	3	4 4 4 4
oedema	1	3 3 3 3
	2	3 - - -
	3	3 3 3 3

Applicant's summary and conclusion

Interpretation of results:

Category 1 (corrosive) based on GHS criteria

Conclusions:

Sodium isobutyl xanthate can be assessed as a substances strongly irritating skin of rabbits

Executive summary:

Severe effects seen in three rabbits.  Study terminated after 3 days for humane reasons