Sodium O-isobutyl dithiocarbonate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March, 1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Proxan-sodium

EC Number:

205-443-5

EC Name:

Proxan-sodium

Cas Number:

140-93-2

Molecular formula:

C4H8OS2.Na

IUPAC Name:

sodium O-isopropyl dithiocarbonate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

Male and female rats aged approximaeely 12 weeks, were used at each dose level. Four animals of one sex were housed in each cage. The animals were weighed, fasted overnight.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

The calculated dose of material administered by intraoesophageal intubation using a ball point needle fitted to a syringe. After dosing food and water were freely available throughout a 9 day observation period

Doses:

200, 400, 800 and 1600 mg/L

No. of animals per sex per dose:

4 male and 4 female

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 800 mg/kg bw

Based on:

test mat.

Mortality:

2 male and 3 femalle at 800 mg/kg ; all animals at 1600 mg/kg

Clinical signs:

other: Rats showed signs of lethargy and died following a period of coma.

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

The LC50 via the oral route in rats was determined to be approximately 800 mg/kg bw.