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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Ma
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
not specified
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Proxan-sodium
EC Number:
205-443-5
EC Name:
Proxan-sodium
Cas Number:
140-93-2
Molecular formula:
C4H8OS2.Na
IUPAC Name:
sodium O-isopropyl dithiocarbonate

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Details on dermal exposure:
The method of Noakes and Sanderson was used. Groups of rats of each sex, aged 12-13 weeks, were used at each dose level. The test material was placed onto the shorn dorsa-lumbar skin and bandaged into contact with the skin using an impermeable dressing of aluminium foil and waterproof plaster.
Duration of exposure:
24 hours
Doses:
1000 mg/kg
No. of animals per sex per dose:
4 male, 4 female
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw
Based on:
test mat.
Mortality:
I animal died (female)
Clinical signs:
There was no toxic reaction in the surving animals.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 via the dermal route in rats was greater than 1000 mg/L.

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