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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Ma
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
not specified
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Proxan-sodium
EC Number:
205-443-5
EC Name:
Proxan-sodium
Cas Number:
140-93-2
Molecular formula:
C4H8OS2.Na
IUPAC Name:
sodium O-isopropyl dithiocarbonate

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Details on dermal exposure:
The method of Noakes and Sanderson was used. Groups of rats of each sex, aged 12-13 weeks, were used at each dose level. The test material was placed onto the shorn dorsa-lumbar skin and bandaged into contact with the skin using an impermeable dressing of aluminium foil and waterproof plaster.
Duration of exposure:
24 hours
Doses:
1000 mg/kg
No. of animals per sex per dose:
4 male, 4 female
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw
Based on:
test mat.
Mortality:
I animal died (female)
Clinical signs:
other: There was no toxic reaction in the surving animals.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 via the dermal route in rats was greater than 1000 mg/L.