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EC number: 246-805-2 | CAS number: 25306-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
- 10% water solution, pH 10.5: 5mg/eye – Mild irritation occurred immediately after instillation. After 1h the eyes appeared normal.
- 36,3% water solution, pH 10.0: 42,5 mg/eye – the concentration solution of the compounds can be consider as substances causing eye corrosion
The dermal LD50was <1000 mg/kg
Sodium ethyl xanthate(CAS# 140-90-9) or sodium isobutyl xanthate (CAS # 25306-75-6) can be assessed as a substances strongly irritating skin of rabbits – IIPC factor accordingly 6.2 or 7.0.(The Institute of Organic Industry Branch of Pszczyna Toxicology Department, March 1998)
Sodium or potassium xanthates dissolved in water undergoes hydrolysis giving alkaline reaction. When xanthates are produced as a water solutions exes of alkali hydroxide is kept (pH >10) as a decomposition inhibitor.
Human information
Harmful and irritating in contact with skin. Contact may result in defatting of the skin, rash and dermatitis. Water solution containing sodium hydroxide may cause skin corrosion. Prolonged or repeated contact may result in burns. May be absorbed through skin with toxic effects.(Canadian Centre for Occupational Health and Safety , CHEMINFO sodium ethyl xanthate, 03.08.2004)
A single case was reported of a worker exposed to xanthate powder and water solution by extensive skin contamination during mixing process of the flotation chemicals. Extensive skin contamination of the worker's skin was evident, from the chest down his skin stained green. The worker experienced abdominal pain, loss of appetite, nausea, vomiting, headache and felt faint, the illness began twenty hours after exposure and lasted for three days. He did not experience skin irritation except for some mild pruritus at the wrists. TTCA (2-thiothiazolidine-4-carboxilic acid), a metabolite of carbon disulfide, was detected in his urine sample.(Donoghue A.M., 1998, Occup. Med. vol. 48, No 7, pp469-470)
Mild dermatitis of sodium ethyl xanthate(CAS# 140-90-9) is the only lesion observed to date in man.(Gosselin R.E.at all, Clinical Toxicology of Commercial Products, 4th ed. Baltimore: Williams and Wilkinson, 1976 , II-211; http:// toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp )
Sodium isopropyl xanthate(CAS# 140-93-2)irritating to skin, eyes, mucous membrane, respiratory tract(The Merck Index , 9th ed., Merck & Co., Inc., 1976 , p. 1116; http:// toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp )
Skin irritation/corrosion
Sodium ethyl xanthate or sodium isobutyl xanthate can be assessed as a substances strongly irritating skin of rabbits – IIPC factor accordingly 6.2 or 7.0.
An assessment of acid or alkali reserve.Sodium or potassium xanthates dissolved in water undergoes hydrolysis giving alkaline reaction. When xanthates are produced as a water solutions exes of alkali hydroxide is kept (pH >10) as a decomposition inhibitor.
A 32 year old male during a xanthate solution preparing became cover in xanthate powder and water solution staining his skin green from the chest down. Twenty hours later ,he experienced abdominal pain, loss of appetite, nausea, vomiting, headache and fatigue, and had mild itchiness at the wrists only. His symptoms resolved within 4 days. Many of the reported symptoms are consistent with carbon disulfide toxicity. A metabolite of carbon disulfide was detected in his urine.(Donoghue A.M. , Occupational Medicine, Vol. 37, no. 7, 1998, p. 469-470)
Skin irritation or skin corrosion
Effect level:
Test animal: rabbit
10% water solution: 1cm3/kg b.w. or 100mg/kg b.w. – no skin irritation
36,3% water solution: 0.175 cm3/kg b.w. or 73mg/kg b.w. – skin corrosion
Paste : 83.3mg/ cm2or 172.4mg/kg b.w. – skin corrosion
Discussion:
Skin irritation/corrosion
No skin irritation of tested rabbits, after application of 1 cm3/kg of 10% water solution of sodium ethyl xanthate (CAS# 140-90-9) (pH 10.5 – 11) pro shaved skin.
Application of 0.5 cm3of 36.3% water solution of sodium ethyl xanthate(CAS# 140-90-9) or sodium isobutyl xathate(CAS # 25306-75-6) pro 6.25 cm2patch of shaved skin of rabbits(4 hours exposure) cause skin corrosion.
Also skin corrosion was the result of application of 500 mg of potassium isobutyl xanthate (CAS# 13001-46-2) as a paste pro 6 cm3patch of rabbits skin.
Conclusion:
Solid xanthates or concentration solution of the compounds can be consider as substances causing skin corrosion.
Carbon disulphide vapour is a severe eye irritant.
Eye irritation/corrosion
An assessment of acid or alkali reserve.
Sodium or potassium xanthates dissolved in water undergoes hydrolysis giving alkaline reaction. When xanthates are produced as a water solutions exes of an alkali hydroxide is kept (pH >10) as a decomposition inhibitor.
Eye irritation/ corrosion
Effect level:
Test animal: rabbit
Discussion/conclusion:
Eye irritation/corrosion
42.4 mg/eye as water solution (pH=10.0), containing 424,1g/dm3of sodium ethyl xanthate (CAS# 140-90-9) or 45.6 mg/eye as water solution pH=10.1, containing 456,1g/dm3of sodium isobutyl xathate (CAS # 25306-75-6), was introduced into the conjunctival sacs of the right rabbit eyes.
Sodium ethyl xanthate (CAS# 140-90-9) or sodium isobutyl xathate (CAS # 25306-75-6) should be consider as seriously injured substance of the rabbit eyes.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
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