Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Testing of xanthates by animal or non-animal metods is not considered possible. 

Animal testing is not permitted on corrosive or strongly irritant substances

In-vitro methods rely on aqueous test systems and the substance will rapidly hydrolyse to alcohol and carbon disulphide. 

In-vitro assessments have been performed and these give a strong prediction for positive skin sensitisation. It is proposed to classifiy as Skin Sens 1. 

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
skin sensitisation, other
Type of information:
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
equivalent or similar to guideline
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Principles of method if other than guideline:
Skin Sensitization Test compatible with OECD429 guidance.The final conclusion is a conclusion made by the reviewer, taking into account all the available evidence, including the in-silico and available experimental results.
GLP compliance:

The final conclusion is that the tested sodium O-ethyl dithiocarbonate (CAS# 140-90-9) is considered to be threatening to humans from this evaluation.

The probability that the prediction is accurate is 80%.

The compound is predicted to be VERY active.

The projected sensitization activity is 55.0 CASE units.

Case units: active = 30 – 80; inactive = 10 – 19; marginal = 20 – 29 .

Interpretation of results:
Category 1 (skin sensitising) based on GHS criteria
Migrated information Criteria used for interpretation of results: expert judgment
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification