Registration Dossier
Registration Dossier
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EC number: 246-805-2 | CAS number: 25306-75-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish, juvenile growth test
- Type of information:
- read-across from similar mixture/product
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- One of two read-across studies within group of low molecular weight alkyl xanthates groups. Short term fish testing shows similar level of effects between members of the group and between sodium and potassium salts.
Flow-through test considered valid for read-across for purposes of classification.
No further vertebrate testing can be justified. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 215 (Fish, Juvenile Growth Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- Details of analysis were not reported in the review document
- Vehicle:
- not specified
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Test type:
- flow-through
- Water media type:
- freshwater
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.1 - < 1 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 28 d
- Dose descriptor:
- other: LC100
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- Under flow test condition concentrations are nominal, but the toxicant is continuously added to water stream to keep the actual concentrations
- Conclusions:
- A flow through test appears to result in higher toxicity than a static test.
Allows classification Aquatic Chronic 3 - Executive summary:
One of two source studies for read-across within group of low molecular weight alkyl xanthates groups. Short term fish testing shows similar level of effects between members of the group and between sodium and potassium salts.
Considered valid for read-across for purposes of classification.
No further vertebrate testing can be justified.
Reference
Description of key information
One of a number of long-term fish studies found on this group of substances
Although lacking details of analysis and not providing a precise LC50 value, the key study is considered suitable for purposes of classification.
The reported toxicity over 28 days with an LC50 of 0.1 - 1.0 mg/l
The EC10 has been assumed to be 0.1 mg/l for purposes of the CSR
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC10
- Effect concentration:
- ca. 0.1 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
