Registration Dossier
Registration Dossier
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EC number: 204-673-3 | CAS number: 124-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP, short documentation. Sex of animals not given. Breath not analysed, purity not specified, reliability of detection method unclear
Data source
Reference
- Reference Type:
- publication
- Title:
- The decomposition of muconic and adipic acids in the animal body.
- Author:
- Mori Y
- Year:
- 1 918
- Bibliographic source:
- J. Biol. Chem. 35, 341-351.
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- Rabbits, 2.7-3.5 kg in weight, were dosed with adipic acid by the s.c. route. Three rabbits were dosed by single administration of 2000mg, one animal was dosed twice (days 1 and 5) and one animal was dosed four times (days 1, 5, 9, 13, 15). Urine was collected and adipic acid and oxalic acid concentrations were monitored.
- GLP compliance:
- no
Test material
- Reference substance name:
- Adipic acid
- EC Number:
- 204-673-3
- EC Name:
- Adipic acid
- Cas Number:
- 124-04-9
- Molecular formula:
- C6H10O4
- IUPAC Name:
- adipic acid
- Details on test material:
- IUCLID4 Test substance: purity not specified
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- subcutaneous
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- In average 61 % of the adipic acid doses were recovered unchanged in the urine, and increase of the oxalic acid concentrations in the urine were observed.
Toxicokinetic parameters
- Toxicokinetic parameters:
- other: In average 61 % of the adipic acid doses were recovered unchanged in the urine, and increase of the oxalic acid concentrations in the urine were observed.
Any other information on results incl. tables
In average 61 % of the adipic acid doses were recovered unchanged in the urine, and increase of the oxalic acid
concentrations in the urine were observed.
Applicant's summary and conclusion
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