Registration Dossier
Registration Dossier
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EC number: 204-673-3 | CAS number: 124-04-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP, short documentation. Sex of animals not given. Breath not analysed, purity not specified, reliability of detection method unclear
Data source
Reference
- Reference Type:
- publication
- Title:
- The decomposition of muconic and adipic acids in the animal body.
- Author:
- Mori Y
- Year:
- 1 918
- Bibliographic source:
- J. Biol. Chem. 35, 341-351.
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- Rabbits, 2.7-3.5 kg in weight, were dosed with adipic acid by the s.c. route. Three rabbits were dosed by single administration of 2000mg, one animal was dosed twice (days 1 and 5) and one animal was dosed four times (days 1, 5, 9, 13, 15). Urine was collected and adipic acid and oxalic acid concentrations were monitored.
- GLP compliance:
- no
Test material
- Reference substance name:
- Adipic acid
- EC Number:
- 204-673-3
- EC Name:
- Adipic acid
- Cas Number:
- 124-04-9
- Molecular formula:
- C6H10O4
- IUPAC Name:
- adipic acid
- Details on test material:
- IUCLID4 Test substance: purity not specified
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- subcutaneous
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- In average 61 % of the adipic acid doses were recovered unchanged in the urine, and increase of the oxalic acid concentrations in the urine were observed.
Toxicokinetic parameters
- Toxicokinetic parameters:
- other: In average 61 % of the adipic acid doses were recovered unchanged in the urine, and increase of the oxalic acid concentrations in the urine were observed.
Any other information on results incl. tables
In average 61 % of the adipic acid doses were recovered unchanged in the urine, and increase of the oxalic acid
concentrations in the urine were observed.
Applicant's summary and conclusion
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