Registration Dossier

Toxicological information

Sensitisation data (human)

Currently viewing:

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: case reports
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
SIDS Initial Assessment Report for SIAM 18 for Adipic acid
Author:
OECD/SIDS
Year:
2004
Bibliographic source:
published by UNEP
Report date:
2004

Materials and methods

Type of sensitisation studied:
respiratory
skin
Study type:
case report
Principles of method if other than guideline:
no guideline followed

Test material

Constituent 1
Chemical structure
Reference substance name:
Adipic acid
EC Number:
204-673-3
EC Name:
Adipic acid
Cas Number:
124-04-9
Molecular formula:
C6H10O4
IUPAC Name:
adipic acid
Constituent 2
Reference substance name:
Hexanedioic acid
IUPAC Name:
Hexanedioic acid
Details on test material:
Purity is 99.8%

Method

Type of population:
occupational

Results and discussion

Results of examinations:
Despite the wide use of adipic acid, only very few cases of skin or respiratory tract reactions are reported:

A positive patch test reaction to adipic acid (probably 1 % in alcoholic solution) was reported in a 51-year-old machine repairman with a 3- to 4-year history of work-related dermatitis of the hands and other exposed sites when working with powders in the synthesis of polyesters (Guin 2001).
Delayed cutaneous hypersensitivity to adipic acid was reported in a patch test (100 %) with a laboratory worker in a factory producing polyester resins. No further details are available in this case (Malten and Zielhuis 1964).
Two cases of bronchial asthma were reported in workers of a pharmaceutical factory coming into contact with spiramycin adipate powder. One of the workers developed an immediate asthmatic reaction also after inhalation of an aerosolized solution (10 mg/ml) of adipic acid. The reaction was reproducible and inhibited by previous administration of sodium cromoglycate. These findings suggested a hypersensitivity reaction to adipic acid by this patient (Moscato et al. 1984).

Applicant's summary and conclusion